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BMJ. 2007 October 27; 335(7625): 850.
PMCID: PMC2043421
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MRSA may kill more US citizens than HIV

Methicillin resistant Staphylococcus aureus (MRSA) is a major public health problem in the US. The incidence of invasive infections such as bacteraemia, pneumonia, and cellulitis reached 31.8 per 100 000 in 2005, according to a population based surveillance programme operating in nine diverse states. The rate of MRSA infection in 2005 was higher than the combined rates of invasive pneumococcal disease (14.1/100 000), invasive group A streptococcus (3.6/100 000), invasive meningococcal disease (0.35/100 000), and invasive Haemophilus influenzae (1.4/100 000), says an editorial (p 1803). MRSA was associated with an estimated 18 650 hospital deaths in 2005. If these figures are accurate, MRSA killed more US citizens that year than HIV.

Most invasive MRSA is still associated with some kind of healthcare risk factor such as surgery, previous colonisation, or an indwelling vascular catheter. In this analysis, over half the patients with healthcare associated infections became ill in the community. But many were infected with a genotype prevalent in hospitals. Patients are probably being colonised in hospital, then developing invasive infections once they get home, says the editorial. Controlling the disease will require collaboration between healthcare professionals in both sectors.


  • JAMA 2007;298:1763-71

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