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Mol Med. 2002 December; 8(12): 763–770.
PMCID: PMC2039970

Extracellular signals and pancreatic beta-cell development: a brief review.


Cell lineage development is a finely tuned process of proliferation and differentiation, survival and apoptosis, that is regulated by numerous extracellular signals. Here we review some of the extracellular signals--including insoluble cell-cell and extracellular matrix-cell interactions, as well as soluble factors--that appear critical for pancreatic beta-cell development. Knowledge of how these signals control the development of pancreatic endocrine stem/precursor cells into fully functional insulin-secreting beta cells is a platform for the restoration of beta-cell function and the cure therapy of type 1 diabetes.

Articles from Molecular Medicine are provided here courtesy of The Feinstein Institute for Medical Research at North Shore LIJ