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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Pharmacol Ther. Author manuscript; available in PMC 2008 May 1.
Published in final edited form as:
Pharmacol Ther. 2007 May; 114(2): 155–170.
Published online 2007 February 24. doi: 10.1016/j.pharmthera.2007.01.010

Fig. 7

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Hypothetical model of signal transduction pathways involved in Ha-ras-mediated AEG-1 induction. Ha-ras activates the PI3K signaling cascade resulting in increased binding of Myc-Max to the AEG-1 promoter and augments AEG-1 expression. AEG-1 activates the NF-κB pathway that regulates expression of genes involved in migration and invasion and thus plays a crucial role in Ha-ras-mediated tumor progression.

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