PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of brjcancerBJC HomepageBJC Advance online publicationBJC Current IssueSubmitting an article to BJCWeb feeds
 
Br J Cancer. 1994 November; 70(5): 1000–1003.
PMCID: PMC2033564

Bladder and kidney function after cure of pelvic rhabdomyosarcoma in childhood.

Abstract

Eleven survivors of pelvic rhabdomyosarcoma underwent bladder function studies and upper urinary tract evaluation at a mean of 6.6 years after completion of therapy, which included a conservative, bladder-sparing surgical policy. Primary tumour sites were: bladder base/prostate, 6; bladder dome, 1; vagina, 2; and pelvic side wall, 2. Seven children (five bladder base/prostate, one vagina and one pelvic side wall tumours) had received irradiation to the pelvis with external beam alone, brachytherapy or both. All seven of these patients had markedly reduced functional bladder capacity (11-48% of mean expected value for age) and abnormal voiding patterns, though bladder compliance was not reduced and bladder emptying was almost complete in five cases. Four of these children also had upper tract dilatation and two required reconstructive bladder surgery because of severe bilateral hydronephrosis. By contrast, each of four children treated without radiotherapy had a normal functional bladder capacity and a normal voiding pattern. all survivors of pelvic rhabdomyosarcoma, especially those who have received radiotherapy, should be carefully monitored for dysfunction of both lower and upper urinary tracts. The frequency-volume voiding chart is a sensitive and easily accomplished method of assessing bladder function in these patients.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (712K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Atra A, Ward HC, Aitken K, Boyle M, Dicks-Mireaux C, Duffy PG, Mitchell CD, Plowman PN, Ransley PG, Pritchard J. Conservative surgery in multimodal therapy for pelvic rhabdomyosarcoma in children. Br J Cancer. 1994 Nov;70(5):1004–1008. [PMC free article] [PubMed]
  • Broecker BH, Plowman N, Pritchard J, Ransley PG. Pelvic rhabdomyosarcoma in children. Br J Urol. 1988 May;61(5):427–431. [PubMed]
  • Crist WM, Garnsey L, Beltangady MS, Gehan E, Ruymann F, Webber B, Hays DM, Wharam M, Maurer HM. Prognosis in children with rhabdomyosarcoma: a report of the intergroup rhabdomyosarcoma studies I and II. Intergroup Rhabdomyosarcoma Committee. J Clin Oncol. 1990 Mar;8(3):443–452. [PubMed]
  • Ghavimi F, Herr H, Jereb B, Exelby PR. Treatment of genitourinary rhabdomyosarcoma in children. J Urol. 1984 Aug;132(2):313–319. [PubMed]
  • Grosfeld JL, Weber TR, Weetman RM, Baehner RL. Rhabdomyosarcoma in childhood: analysis of survival in 98 cases. J Pediatr Surg. 1983 Apr;18(2):141–146. [PubMed]
  • Hays DM, Raney RB, Jr, Lawrence W, Jr, Tefft M, Soule EH, Crist WM, Foulkes M, Maurer HM. Primary chemotherapy in the treatment of children with bladder--prostate tumors in the Intergroup Rhabdomyosarcoma Study (IRS-II). J Pediatr Surg. 1982 Dec;17(6):812–820. [PubMed]
  • Hays DM, Lawrence W, Jr, Crist WM, Wiener E, Raney RB, Jr, Ragab A, Tefft M, Webber B, Johnston J, Maurer HM. Partial cystectomy in the management of rhabdomyosarcoma of the bladder: a report from the Intergroup Rhabdomyosarcoma Study. J Pediatr Surg. 1990 Jul;25(7):719–723. [PubMed]
  • Koff SA. Estimating bladder capacity in children. Urology. 1983 Mar;21(3):248–248. [PubMed]
  • La Quaglia MP, Ghavimi F, Herr H, Mandell L, Pennenberg D, Hajdu S, Exelby PR. Prognostic factors in bladder and bladder-prostate rhabdomyosarcoma. J Pediatr Surg. 1990 Oct;25(10):1066–1072. [PubMed]
  • McLorie GA, Abara OE, Churchill BM, Greenberg M, Mancer K. Rhabdomyosarcoma of the prostate in childhood: current challenges. J Pediatr Surg. 1989 Oct;24(10):977–981. [PubMed]
  • Massad CA, Kogan BA, Ablin AR. Organ preservation in the management of pelvic rhabdomyosarcoma. Urol Int. 1991;46(3):279–282. [PubMed]
  • Maurer HM, Beltangady M, Gehan EA, Crist W, Hammond D, Hays DM, Heyn R, Lawrence W, Newton W, Ortega J, et al. The Intergroup Rhabdomyosarcoma Study-I. A final report. Cancer. 1988 Jan 15;61(2):209–220. [PubMed]
  • Ortega JA. A therapeutic approach to childhood pelvic rhabdomyosarcoma without pelvic exenteration. J Pediatr. 1979 Feb;94(2):205–209. [PubMed]
  • Raney RB, Jr, Gehan EA, Hays DM, Tefft M, Newton WA, Jr, Haeberlen V, Maurer HM. Primary chemotherapy with or without radiation therapy and/or surgery for children with localized sarcoma of the bladder, prostate, vagina, uterus, and cervix. A comparison of the results in Intergroup Rhabdomyosarcoma Studies I and II. Cancer. 1990 Nov 15;66(10):2072–2081. [PubMed]
  • Tefft M, Hays D, Raney RB, Jr, Lawrence W, Soule E, Donaldson MH, Sutow WW, Gehan E. Radiation to regional nodes for rhabdomyosarcoma of the genitourinary tract in children: is it necessary? A report from the Intergroup Rhabdomyosarcoma Study No. 1 (IRS-1). Cancer. 1980 Jun 15;45(12):3065–3068. [PubMed]
  • Voûte PA, Vos A, de Kraker J, Behrendt H. Rhabdomyosarcomas: chemotherapy and limited supplementary treatment program to avoid mutilation. Natl Cancer Inst Monogr. 1981 Apr;(56):121–125. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK