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Arch Dis Child. 1970 April; 45(240): 193–195.
PMCID: PMC2020284

Metronidazole and Niridazole combined with Dehydroemetine in Treatment of Children with Amoebic Liver Abscess


Metronidazole combined with dehydroemetine cured 13 of 15 children with amoebic liver abscess. An alternative combination of niridazole with dehydroemetine produced cure in 13 of 14 children. No relapses were observed. Electrocardiographic changes were noted in 2 of the first group and in 5 of those who received the second regimen. The results are similar to those obtained with emetine preparations combined with chloroquine. Either metronidazole or niridazole are effective substitutes for chloroquine and of these preparations metronidazole is preferred.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Powell SJ. The cardiotoxicity of systemic amebicides. A comparative electrocardiographic study. Am J Trop Med Hyg. 1967 Jul;16(4):447–450. [PubMed]
  • Powell SJ, Scragg JN, Rubidge CJ, Naidoo BT. Further trials of niridazole in urinary tract bilharziasis. S Afr Med J. 1968 Jul 27;42(29):760–761. [PubMed]
  • Powell SJ, Wilmot AJ, Elsdon-Dew R. Further trials of metronidazole in amoebic dysentery and amoebic liver abscess. Ann Trop Med Parasitol. 1967 Dec;61(4):511–514. [PubMed]
  • SCRAGG J. Amoebic liver abscess in African children. Arch Dis Child. 1960 Apr;35:171–176. [PMC free article] [PubMed]
  • Scragg JN, Powell SJ. Emetine hydrochloride and chloroquine in the treatment of children with amoebic liver abscess. Arch Dis Child. 1966 Oct;41(219):549–550. [PMC free article] [PubMed]

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