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Can Fam Physician. 2001 July; 47: 1385–1387.
PMCID: PMC2018535

Maternal obesity and risk of neural tube defects.

Abstract

QUESTION: One of my patients is taking olanzapine for schizophrenia. She has gained a lot of weight, which, I understand, often happens with some of the new atypical antipsychotics. Due to her weight gain, she failed to notice she had become pregnant. Is she at risk? ANSWER: Experience with olanzapine is relatively slight, but available prospective data do not show increased teratogenic risk. Adiposity, on the other hand, is associated with increased risk of neural tube defects. Only some of this risk can be reduced by folate supplementation.


Articles from Canadian Family Physician are provided here courtesy of College of Family Physicians of Canada