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doi: 10.2119/2007-00065.Shanley

Table 3B

Gene Networks Upregulated Uniquely on Day Three

Network and Central Node(s)1Ingenuity Annotations2Panther Classifications3
  • Pathway (P value)
  • Biological Process (P value)
  • Molecular Function (P value)
D.A.V.I.D. Functional Annotation4
  • Category
  • Term
  • P value
Network 1 FOS and IL1A
  • Immune response
  • Connective tissue disorders
  • Inflammatory disease
  • Immunity and defense
  • Inflammation mediated by chemokine and cytokine signaling (6.0E-5)
  • Cytokine receptor (1.5E-09)
  • Defense response
  • 7.7E-11
Network 2 MAPK1
  • Cellular movement
  • Hematologic system Development
  • Immune response
  • Toll receptor signaling pathway (4.0E-10)
  • Proteolysis (2.9E-12)
  • Serine protease (3.6E-9)
  • Signal
  • 1.3E-9
Network 3 SP1
  • Inflammatory disease
  • Hematologic system development
  • Immune response
  • Plasminogen activating cascade (3.3E-4)
  • Immunity and defense (3.2E-8)
  • Complement component (3.8E-5)
  • Direct protein sequencing
  • 2.7E-9
Network 4 STAT3 and STAT5
  • Cellular movement
  • Cell morphology
  • Cellular function and maintenance
  • PDGF signaling pathway (1.4E-10)
  • Signal transduction (1.2E-16)
  • Non-receptor tyrosine protein kinase (2.6E-09)
  • Phosphorylation
  • 2.2E-14
Network 5 NFKB1A
  • Cell death
  • Cancer
  • Hematologic disease
  • Insulin/IGF pathway-protein kinase B signaling pathway (1.7E-7)
  • Apoptosis (2.5E-8)
  • Membrane traffic protein (1.3E-3)
  • Protein binding
  • 1.4E-9
1See Table 3A. FOS, c-fos; IL1A, interleukin 1α; MAPK1, mitogen activated protein kinase one (a.k.a. ERK2); SP1, Sp1 transcription factor; STAT3, signal transducer and activator of transcription 3; STAT5B, signal transducer and activator of transcription factor 5B; NFKB1A, nuclear factor of κ light polypeptide gene enhancer in B-cells α (a.k.a. IκBα).
2,3,4See Table 3A.