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Br J Cancer. 1979 May; 39(5): 536–539.
PMCID: PMC2009905

Elastosis and response to endocrine therapy in human breast cancer.


Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross elastosis, indicating that this simple method might provide a useful predictive index for response to endocrine therapy. In addition, tumours with oestrogen-receptor activity (a feature associated with a high rate of response) but with no elastosis were unlikely to respond, suggesting that a combination of the 2 predictive indices might be more valuable than either taken alone.

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Selected References

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  • Azzopardi JG, Laurini RN. Elastosis in breast cancer. Cancer. 1974 Jan;33(1):174–183. [PubMed]
  • Fisher ER, Gregorio RM, Fisher B, Redmond C, Vellios F, Sommers SC. The pathology of invasive breast cancer. A syllabus derived from findings of the National Surgical Adjuvant Breast Project (protocol no. 4). Cancer. 1975 Jul;36(1):1–85. [PubMed]
  • King RJ, Hayward JL, Kumaoka S, Yamamoto H. Comparison of soluble oestrogen and progestin receptor content of primary breast tumours from Japan and Britain. Eur J Cancer. 1977 Sep;13(9):967–970. [PubMed]
  • Lundmark C. Breast cancer and elastosis. Cancer. 1972 Nov;30(5):1195–1201. [PubMed]
  • Masters JR, Sangster K, Hawkins RA, Shivas AA. Elastosis and oestrogen receptors in human breast cancer. Br J Cancer. 1976 Mar;33(3):342–343. [PMC free article] [PubMed]
  • Masters JR, Hawkins RA, Sangster K, Hawkins W, Smith II, Shivas AA, Roberts MM, Forrest AP. Oestrogen receptors, cellularity, elastosis and menstrual status in human breast cancer. Eur J Cancer. 1978 Mar;14(3):303–307. [PubMed]
  • Roberts MM, Rubens RD, King RJ, Hawkins RA, Millis RR, Hayward JL, Forrest AP. Oestrogen receptors and the response to endocrine therapy in advanced breast cancer. Br J Cancer. 1978 Sep;38(3):431–436. [PMC free article] [PubMed]
  • Shivas AA, Douglas JG. The prognostic significance of elastosis in breast carcinoma. J R Coll Surg Edinb. 1972 Sep;17(5):315–320. [PubMed]
  • Wallgren A, Silfverswärd C, Eklund G. Prognostic factors in mammary carcinoma. Acta Radiol Ther Phys Biol. 1976 Feb;15(1):1–16. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK