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Br J Cancer. 1970 June; 24(2): 226–234.
PMCID: PMC2008582

Epidemiological Characteristics of Breast Cancer in Middle and Late Age


International rates of breast cancer for females aged 40-44 years (the “early” rate) and for females aged 65-69 years (the “late” rate) were positively correlated with sugar and fat intakes. The correlation explained three-quarters of the variation in the late rate, for 22 countries, but only half of the variation in the early rate. The late rate was, further, positively correlated with estimates of the percentage of nulliparous women (9 populations) and, together with terms for sugar and fat intakes, the multiple regression explained 90% of the variation. Early registration rates (13 populations) were positively correlated with blood group A which appeared, from the multiple regression equation, to contribute more than twice the amount to the early rate than did sugar and fat intakes. The contribution of blood group A to the late rate appeared to be only one-third of that for sugar and fat intakes.

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Selected References

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  • Carroll KK, Gammal EB, Plunkett ER. Dietary fat and mammary cancer. Can Med Assoc J. 1968 Mar 23;98(12):590–594. [PMC free article] [PubMed]
  • Cole P, MacMahon B. Oestrogen fractions during early reproductive life in the aetiology of breast cancer. Lancet. 1969 Mar 22;1(7595):604–606. [PubMed]
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  • de WAARD, de LAIVE J, BAANDERS-VANHALEWIJN EA. On the bimodal age distribution of mammary carcinoma. Br J Cancer. 1960 Sep;14:437–448. [PMC free article] [PubMed]
  • de Waard F. The epidemiology of breast cancer: review and prospects. Int J Cancer. 1969 Sep 15;4(5):577–586. [PubMed]
  • WYNDER EL, BROSS IJ, HIRAYAMA T. A study of the epidemiology of cancer of the breast. Cancer. 1960 May-Jun;13:559–601. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK