Search tips
Search criteria 


Logo of brjcancerBJC HomepageBJC Advance online publicationBJC Current IssueSubmitting an article to BJCWeb feeds
Br J Cancer. 1986 February; 53(2): 281–284.
PMCID: PMC2001334

Abortion before first livebirth and risk of breast cancer.


The present study examined the association between abortion prior to a first livebirth and breast cancer risk among a cohort of 3,315 women who had been delivered of liveborn children between 1946 and 1965 in a group of private gynaecology practices in Connecticut and followed through 1980 for the incidence of cancer. Among women with one livebirth at the time of cohort identification, a spontaneous abortion before this livebirth was associated with a 3.5-fold increase in the risk of breast cancer. The elevation in risk was independent of some of the major risk factors of breast cancer and became more pronounced as the number of years since the abortion increased.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (600K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • BERKSON J, GAGE RP. Calculation of survival rates for cancer. Proc Staff Meet Mayo Clin. 1950 May 24;25(11):270–286. [PubMed]
  • Devesa SS, Pollack ES, Young JL., Jr Assessing the validity of observed cancer incidence trends. Am J Epidemiol. 1984 Feb;119(2):274–291. [PubMed]
  • Greenberg ER, Barnes AB, Resseguie L, Barrett JA, Burnside S, Lanza LL, Neff RK, Stevens M, Young RH, Colton T. Breast cancer in mothers given diethylstilbestrol in pregnancy. N Engl J Med. 1984 Nov 29;311(22):1393–1398. [PubMed]
  • Hadjimichael OC, Meigs JW, Falcier FW, Thompson WD, Flannery JT. Cancer risk among women exposed to exogenous estrogens during pregnancy. J Natl Cancer Inst. 1984 Oct;73(4):831–834. [PubMed]
  • Pike MC, Henderson BE, Casagrande JT, Rosario I, Gray GE. Oral contraceptive use and early abortion as risk factors for breast cancer in young women. Br J Cancer. 1981 Jan;43(1):72–76. [PMC free article] [PubMed]
  • Russo J, Russo IH. Susceptibility of the mammary gland to carcinogenesis. II. Pregnancy interruption as a risk factor in tumor incidence. Am J Pathol. 1980 Aug;100(2):497–512. [PubMed]
  • Vessey MP, McPherson K, Yeates D, Doll R. Oral contraceptive use and abortion before first term pregnancy in relation to breast cancer risk. Br J Cancer. 1982 Mar;45(3):327–331. [PMC free article] [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK