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Br Med J. 1969 February 8; 1(5640): 357–358.
PMCID: PMC1982610

Comparison of Preseasonal and Coseasonal Allpyral with Depo-Medrone in Summer Hay-fever

Abstract

Three hundred patients with grass pollen hay-fever, with or without pollen asthma, were given one of three forms of treatment: preseasonal or coseasonal alum-precipitated pyridine extracted grass pollen (Allpyral) or methylprednisolone acetate in slow-release form (Depo-Medrone). Significant improvement was obtained with preseasonal Allpyral and with Depo-Medrone, but the degree of improvement obtained with coseasonal Allpyral fell within the limits of placebo response.

Nevertheless, it is considered that the definite suppression of the pituitary-adrenal function which results from the use of a long-term steroid is not justified in a benign condition such as hay-fever.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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  • Bain LS, Balch HW, Jacomb RG. Parenteral administration of 6-alpha-methylprednisolone-21- acetate. I. Intra-articular injection: comparison with hydrocortisone acetate. Ann Phys Med. 1967 May;9(2):43–48. [PubMed]
  • BROWN EA. The treatment of allergy to ragweed pollen by means of a single annual injection of emulsified pollen extract. VI. Discussion of results, relationships and some miscellaneous factors. Ann Allergy. 1959 May-Jun;17(3):358–379. [PubMed]
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  • Harris MC. HAY FEVER-A Comparative Clinical Evaluation of Treatment with Aqueous Pollen Extracts, Alum-Precipitated Pyridine Pollen Extracts and Aqueous Pollen in Oil Emulsions. Calif Med. 1962 Nov;97(5):286–290. [PMC free article] [PubMed]
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  • Pearson RS. Depot Injections in Treatment of Hay-fever and Pollen Asthma. Br Med J. 1965 Nov 13;2(5471):1148–1152. [PMC free article] [PubMed]
  • TREADWELL BL, SALVAGE O, SEVER ED, COPEMAN WS. Pituitary-adrenal function during corticosteroid therapy. Lancet. 1963 Feb 16;1(7277):355–358. [PubMed]
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