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Br J Cancer. 1990 December; 62(6): 1026–1030.
PMCID: PMC1971548

International variations in the incidence of childhood renal tumours.


The International Agency for Research on Cancer has coordinated a worldwide study of childhood cancer incidence, with data from over 50 countries. We present here the results on renal tumours. Wilms' tumour was the most common malignant kidney tumour in all regions. It is sometimes considered to be an 'index cancer of childhood' but it is clear from the present study that there is at least a threefold difference in incidence between the age-standardised annual rates of over 10 per million in the Black populations in the United States and Nigeria and those of around three per million in several East Asian populations. In White Caucasian populations, Wilms' tumour had an annual incidence of 6-9 per million, accounting for 5-7% of all childhood cancer. It was almost everywhere equally common in boys and girls, but the sex ratio in East Asia was M/F = 1.4:1. Age distributions were similar among White Caucasian and Black populations, with the peak incidence in the second year of life. In East Asia, however, 25-40% of the total incidence occurred in infants aged under 1 year, compared with around 15% in many Western series. Other studies have shown that, in the United States, Wilms' tumour has a lower incidence among Asian children than among Whites or Blacks and tends to occur at a younger age. The variation in patterns of incidence of Wilms' tumour along ethnic rather than geographical lines suggests that genetic predisposition is important in its aetiology. Renal carcinoma in childhood is rare throughout the world, with little sign of international variation. It accounted for a higher proportion of childhood renal tumours in East Asia but this was attributable to the lower incidence of Wilms' tumour in that region.

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Selected References

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  • Birch JM, Marsden HB. A classification scheme for childhood cancer. Int J Cancer. 1987 Nov 15;40(5):620–624. [PubMed]
  • Bolande RP. Congenital and infantile neoplasia of the kidney. Lancet. 1974 Dec 21;2(7895):1497–1499. [PubMed]
  • Bonnin JM, Rubinstein LJ, Palmer NF, Beckwith JB. The association of embryonal tumors originating in the kidney and in the brain. A report of seven cases. Cancer. 1984 Nov 15;54(10):2137–2146. [PubMed]
  • Breslow NE, Beckwith JB. Epidemiological features of Wilms' tumor: results of the National Wilms' Tumor Study. J Natl Cancer Inst. 1982 Mar;68(3):429–436. [PubMed]
  • Breslow N, Beckwith JB, Ciol M, Sharples K. Age distribution of Wilms' tumor: report from the National Wilms' Tumor Study. Cancer Res. 1988 Mar 15;48(6):1653–1657. [PubMed]
  • Bunin GR, Nass CC, Kramer S, Meadows AT. Parental occupation and Wilms' tumor: results of a case-control study. Cancer Res. 1989 Feb 1;49(3):725–729. [PubMed]
  • D'Angio GJ, Breslow N, Beckwith JB, Evans A, Baum H, deLorimier A, Fernbach D, Hrabovsky E, Jones B, Kelalis P, et al. Treatment of Wilms' tumor. Results of the Third National Wilms' Tumor Study. Cancer. 1989 Jul 15;64(2):349–360. [PubMed]
  • Goodman MT, Yoshizawa CN, Kolonel LN. Ethnic patterns of childhood cancer in Hawaii between 1960 and 1984. Cancer. 1989 Oct 15;64(8):1758–1763. [PubMed]
  • Innis MD. Nephroblastoma: possible index cancer of childhood. Med J Aust. 1972 Jan 1;1(1):18–20. [PubMed]
  • Kramer S, Meadows AT, Jarrett P. Racial variation in incidence of Wilms' tumor: relationship to congenital anomalies. Med Pediatr Oncol. 1984;12(6):401–405. [PubMed]
  • Lucas SB, Fischer PR. No neuroblastoma in Zaire. Lancet. 1990 Jan 13;335(8681):115–115. [PubMed]
  • Marsden HB, Lawler W. Bone metastasizing renal tumour of childhood. Histopathological and clinical review of 38 cases. Virchows Arch A Pathol Anat Histol. 1980;387(3):341–351. [PubMed]
  • Marsden HB, Lawler W, Carr T, Kumar S. A scoring system for Wilms' tumour: pathological study of the second Medical Research Council (MRC) trial. Int J Cancer. 1984 Mar 15;33(3):365–368. [PubMed]
  • Marsden HB, Newton WA., Jr New look at mesoblastic nephroma. J Clin Pathol. 1986 May;39(5):508–513. [PMC free article] [PubMed]
  • Parkin DM, Stiller CA, Draper GJ, Bieber CA. The international incidence of childhood cancer. Int J Cancer. 1988 Oct 15;42(4):511–520. [PubMed]
  • Virag I, Modan B. Epidemiologic aspects of neoplastic diseases in Israeli immigrant population. II. Malignant neoplasms in childhood. Cancer. 1969 Jan;23(1):137–141. [PubMed]
  • Weeks DA, Beckwith JB, Mierau GW, Luckey DW. Rhabdoid tumor of kidney. A report of 111 cases from the National Wilms' Tumor Study Pathology Center. Am J Surg Pathol. 1989 Jun;13(6):439–458. [PubMed]

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