Search tips
Search criteria 


Logo of brjcancerBJC HomepageBJC Advance online publicationBJC Current IssueSubmitting an article to BJCWeb feeds
Br J Cancer. 1994 May; 69(5): 957–960.
PMCID: PMC1968891

The incidence of anticipatory nausea and vomiting after repeat cycle chemotherapy: the effect of granisetron.


Anticipatory nausea and vomiting (ANV) after repeated cycles of cytotoxic chemotherapy is thought to be a conditioned response to a conditioning stimulus. Good control of acute and delayed emesis may result in a lower incidence of ANV. We have analysed data from 574 chemotherapy patients who received granisetron as their antiemetic treatment during repeat cycle chemotherapy. Per treatment cycle, less than 10% of patients displayed symptoms of anticipatory nausea and 2% or less had symptoms of anticipatory vomiting. It is concluded that the use of granisetron as an antiemetic during the acute phase of chemotherapy may result in a lower incidence of ANV in patients undergoing repeat cycle chemotherapy.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (806K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Andrykowski MA, Redd WH, Hatfield AK. Development of anticipatory nausea: a prospective analysis. J Consult Clin Psychol. 1985 Aug;53(4):447–454. [PubMed]
  • Morrow GR, Arseneau JC, Asbury RF, Bennett JM, Boros L. Anticipatory nausea and vomiting with chemotherapy. N Engl J Med. 1982 Feb 18;306(7):431–432. [PubMed]
  • Morrow GR, Morrell C. Behavioral treatment for the anticipatory nausea and vomiting induced by cancer chemotherapy. N Engl J Med. 1982 Dec 9;307(24):1476–1480. [PubMed]
  • Morrow GR, Lindke J, Black PM. Predicting development of anticipatory nausea in cancer patients: prospective examination of eight clinical characteristics. J Pain Symptom Manage. 1991 May;6(4):215–223. [PubMed]
  • Nesse RM, Carli T, Curtis GC, Kleinman PD. Pretreatment nausea in cancer chemotherapy: a conditioned response? Psychosom Med. 1980 Jan;42(1):33–36. [PubMed]
  • Nicholas DR. Prevalence of anticipatory nausea and emesis in cancer chemotherapy patients. J Behav Med. 1982 Dec;5(4):461–463. [PubMed]
  • Redd WH, Andresen GV, Minagawa RY. Hypnotic control of anticipatory emesis in patients receiving cancer chemotherapy. J Consult Clin Psychol. 1982 Feb;50(1):14–19. [PubMed]
  • Wilcox PM, Fetting JH, Nettesheim KM, Abeloff MD. Anticipatory vomiting in women receiving cyclophosphamide, methotrexate, and 5-FU (CMF) adjuvant chemotherapy for breast carcinoma. Cancer Treat Rep. 1982 Aug;66(8):1601–1604. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK