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Logo of jroyalcgpracBJGP at RCGPBJGP at PubMed CentralJ R Coll Gen Pract at PubMed CentralRCGP homepage
J R Coll Gen Pract. 1986 September; 36(290): 411–412.
PMCID: PMC1960537

Treatment for hypertension interrupted by placebo: the response of patients with high and low general health questionnaire scores


A study is described in which established treatment for hypertension was interrupted by placebo as part of a change to an alternative treatment.

The patients involved were divided into two groups according to their score on the general health questionnaire. All the patients showed an increase in diastolic pressure after the placebo phase of the change-over but the increase was greater for patients with a high score on the general health questionnaire than it was for patients with a low score. For the patients with a high score the diastolic pressure approximated to the level recorded when the diagnosis was first made, but for patients with a low score it was considerably lower than this initial reading.

The implication of this finding for the design of `changeover' studies is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Peart WS. Concepts in hypertension. The Croonian Lecture 1979. J R Coll Physicians Lond. 1980 Jul;14(3):141–152. [PubMed]
  • Mann A. Hypertension: psychological aspects and diagnostic impact in a clinical trial. Psychol Med Monogr Suppl. 1984;5:1–35. [PubMed]
  • Stokoe D, Zuccollo G. Travel sickness in patients attending a geriatric day hospital. Age Ageing. 1985 Sep;14(5):308–311. [PubMed]

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