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The aim was to determine whether lower visceral pain thresholds in irritable bowel syndrome (IBS) primarily reflect physiological or psychological factors.
Firstly, 121 IBS patients and 28 controls underwent balloon distensions in the descending colon using the ascending methods of limits (AML) to assess pain and urge thresholds. Secondly, sensory decision theory analysis was used to separate physiological from psychological components of perception: neurosensory sensitivity (p(A)) was measured by the ability to discriminate between 30 mmHg vs 34 mmHg distensions; psychological influences were measured by the report criterion—that is, the overall tendency to report pain, indexed by the median intensity rating for all distensions, independent of intensity. Psychological symptoms were assessed using the Brief Symptom Inventory (BSI).
IBS patients had lower AML pain thresholds (median: 28 mmHg vs 40 mm Hg; p<0.001), but similar neurosensory sensitivity (median p(A): 0.5 vs 0.5; p=0.69; 42.6% vs 42.9% were able to discriminate between the stimuli better than chance) and a greater tendency to report pain (median report criterion: 4.0 (“mild” pain) vs 5.2 (“weak” pain); p=0.003). AML pain thresholds were not correlated with neurosensory sensitivity (r=−0.13; p=0.14), but were strongly correlated with report criterion (r=0.67; p<0.0001). Report criterion was inversely correlated with BSI somatisation (r=−0.26; p=0.001) and BSI global score (r=−0.18; p=0.035). Similar results were seen for the non‐painful sensation of urgency.
Increased colonic sensitivity in IBS is strongly influenced by a psychological tendency to report pain and urge rather than increased neurosensory sensitivity.
During balloon distension of the rectum or colon patients with irritable bowel syndrome (IBS) report pain and discomfort at abnormally low volumes or pressures.1,2,3 These lower pain thresholds have been interpreted to represent visceral hypersensitivity4,5 and have been attributed to physiological differences in IBS patients.6,7,8 Mertz et al even proposed that lower pain thresholds are “a reliable biological marker of IBS.”9 However, it is impossible to attribute lower IBS pain thresholds specifically to underlying physiological mechanisms3,10 since cognitive and psychological influences affect the reporting of pain and, by extension, affect threshold measurements.1,11,12
The physiological and psychological components that determine pain thresholds can be separately quantified by sensory decision theory analysis (SDT).13 In SDT stimuli of different intensities are presented in an unpredictable order and subjects rate the intensity of each stimulus. Statistical decision theory is then used to determine:
The primary aim of this study was to determine whether differences in pain thresholds between patients with IBS and healthy controls are explained primarily by differences in neurosensory sensitivity (physiological differences) or differences in the overall tendency to report pain (psychological differences). The secondary aim was to determine and explain differences in urge thresholds. Ultimately, a better understanding of the factors that affect these thresholds will improve our understanding of the mechanisms responsible for hypersensitivity and might help to direct therapy. Accordingly, we used AML to compare sensory thresholds in both IBS patients and healthy controls, and SDT supplemented by psychological questionnaires to determine how physiological and psychological factors contribute to these thresholds. We hypothesised that, compared to healthy controls, IBS patients would have: (1) lower AML determined pain and urge thresholds; (2) similar levels of neurosensory sensitivity; and (3) a lower report criterion (that is, an increased overall tendency to report stimuli as intense). (4) We also hypothesised that AML pain thresholds and the report criterion would be inversely correlated with levels of psychological distress.
Subjects were recruited by advertisements or physician referrals and screened by telephone. The study was approved by the institutional review board of the University of North Carolina (UNC) and all subjects provided informed consent.
The study population consisted of 132 patients (84% female; median age 35 years) who met Rome II criteria for IBS17 and had current symptom activity (abdominal pain at least once a week in the past month). Twenty‐seven IBS patients were constipation predominant (IBS‐C), 31 were diarrhoea predominant IBS (IBS‐D), and 61 were not classifiable as either. These subjects had no history of gastrointestinal resection (other than appendectomy or cholecystectomy), known IBS, coeliac disease, lactose malabsorption, heart disease, or diabetes mellitus, and they were not pregnant at the time of study. IBS patients were required to stop the following medications—antidepressants (seven days before study), antispasmodics, muscle relaxants or narcotic analgesics (three days); and non‐steroidal anti‐inflammatory agents (one day).
The control population consisted of 31 subjects (71% female; median age 40 years) without any significant or recurring gastrointestinal symptoms; exclusion criteria were average stool frequency of less than three per week or more than three per day, abdominal pain, use of a laxative or anti‐diarrhoeal agent on more than two occasions over the previous year, history of alcohol or substance abuse, a psychiatric diagnosis, or any of the medical conditions listed above for the IBS patients. None of these healthy subjects had used any antidepressants, antispasmodics, muscle relaxants, or narcotic analgesics for at least one year. Non‐steroidal anti‐inflammatory agents were not permitted for at least one day before the study. There were no significant differences between the IBS group and healthy controls for age (p=0.72) or sex (p=0.12).
On the first day of the study subjects reported to the UNC General Clinical Research Center (GCRC) at 11 am where they completed the Brief Symptom Inventory‐18 (BSI‐18). This is an 18‐item measure of psychological distress along three primary symptom dimensions: somatisation, anxiety, and depression.18 The BSI‐18 was also scored for the global severity index. The rationale for including the BSI somatisation scale is that somatic hypervigilance is hypothesised to play a part in visceral hypersensitivity.12 The BSI depression, anxiety, and global scales were included based on the convention of regarding depression and anxiety as the primary dimensions of psychological distress.
At approximately 4 pm subjects underwent bowel preparation with 3 oz of Fleets Phospho‐Soda followed by an overnight fast. On the morning of the second day (approximately 8 am) a barostat catheter was placed into the descending colon for sensory testing. Firstly, a guide wire was inserted to the level of the splenic flexure using a flexible sigmoidoscope. The sigmoidoscope was then withdrawn and a barostat catheter (Model No C7‐CB‐0026, Mui Scientific, Mississauga, Ontario, Canada) was inserted over the guide wire. The guide wire was then withdrawn and barostat placement was confirmed by fluoroscopy. No sedation was used throughout the duration of this procedure. A 600 ml plastic bag (Model No CT‐BP600R, Mui Scientific, Mississauga, Ontario, Canada) was attached to the catheter, and the catheter was connected to a computer controlled piston type pump (barostat) that was capable of inflating and deflating the bag at a rate of 38 ml/s (G&J Electronics, Willodale, Ontario, Canada). The pump was interfaced to a computer running a software program that recorded the pressure inside the bag 16 times per second.
Subjects were instructed to give separate ratings of the intensity of pain and urgency to defecate experienced at the end of each distension, using a six point scale (0= no sensation; 1=weak; 2=mild; 3=moderate; 4=strong; 5=intense) (fig 11).). The scale was visible to subjects during the procedure. Sample distensions were then performed during which the barostat bag was inflated in a stepwise fashion by increasing bag pressure by 4 mmHg every 15 seconds until the subject reported moderate pain (rating of 3). The purpose of the sample distensions was threefold: (1) to insure that the barostat bag was unfolded; (2) to teach the subject how to use the rating scale to rate the intensity of colonic sensations; and (3) to decrease anticipatory anxiety. The barostat bag was then slowly inflated with 30 ml of air and the pressure was allowed to equilibrate for 3 minutes. The average pressure during the last 15 seconds defined the individual operating pressure (IOP): the minimum pressure required to overcome mechanical forces and inflate the bag with 30 ml of air.
This protocol started approximately 90 minutes following barostat placement. Phasic distensions were 30 seconds in duration and were separated by 30‐second rest intervals starting at the IOP and progressively increasing in 2 mmHg steps until either the subject requested the research nurse to stop the protocol or 48 mmHg was reached. The pain threshold was defined as the amount of pressure above IOP at which the subject first reported moderate pain (absolute distending pressure minus the IOP). If the subject requested that the research nurse stop the trial before moderate pain was reported (for example, because of urge to defecate) then the pain threshold was not determined. If the subject reached 48 mmHg without reporting moderate pain, then the pain threshold was defined as 50 mmHg minus the IOP. The urge threshold was defined analogously.
This protocol started approximately 100 minutes following barostat placement. Subjects were instructed that the purpose was to evaluate how well they could discriminate between different balloon pressures. Twenty‐four 30‐second phasic distensions (eight at 30 mmHg, eight at 32 mmHg, and eight at 34 mmHg) were presented in an unpredictable order separated by 30‐second rest intervals at the IOP. These stimulus intensities were selected to bracket the average pain threshold determined by AML in a previous study of SDT.19 The choice of 2 mmHg increments between stimuli was based on this previous study in which this difference was found to work well (that is, subjects made some errors of classification but discrimination was better than chance).19 This protocol followed the recommendation of McNicol20 and one of the co‐investigators who is an expert on SDT (WCC). The subjects were able to stop the protocol at any time.
Discrimination index (p(A)) and report criterion (B) values for the 30 mmHg vs 34 mmHg stimuli were calculated for each subject using a computer program developed by MN Janal and WC Clark (personal communication). This program was based on formulas taken from McNicol for non‐parameteric SDT analysis of rating scale data.20
The meaning of the discrimination index (p(A)) is clear: it is a measure of the ability to distinguish between the two stimulus intensities, based on the sensory intensity ratings reported in response to them. However, the computational formula is complex: (1) ratings on the rating scale used by the subject to subjectively rate the intensity of stimuli that are presented, are separated by multiple boundaries (fig 11).). (2) For each boundary one calculates the proportion of all the higher intensity stimuli (that is, 34 mmHg distensions) that received ratings above this boundary (this is the “hit” rate for this boundary) and one separately calculates the proportion of the lower intensity stimuli (that is, 30 mmHg distensions) that received ratings above this boundary (this is the “false alarm” rate for this boundary). Thus, in this study hit rates and false alarm rates were calculated for each of five boundaries. (3) These hit rates and false alarm rates are plotted against each other to create a receiver operator characteristic curve (ROC curve) as shown in figure 22.. The curve is drawn by connecting the different intersections of hit and false alarm rates calculated for each boundary (shown by the solid line in fig 22).). (4) P(A) is the total area under the ROC curve (shaded area in fig 22)) expressed as a proportion of the maximum possible area. The broken diagonal line in figure 22 goes through all the points for which the hit rate and the false alarm rates are equal; this represents chance performance or no discrimination, and the index, p(A) is 0.5. All values less than 0.5 are considered chance performance and are rounded up to 0.5. Thus, p(A) is a number between 0.5 (chance) and 1.0 (perfect discrimination) that measures the ability to discriminate between the two intensities independently of what rating labels the subject uses to describe the stimuli.
The report criterion (B) is the median rating assigned by the subjects to all stimuli. Firstly, the ratings assigned to the 30 mmHg distensions were pooled with ratings for the 34 mmHg distensions. Secondly, each response on the six‐point rating scale was assigned an individual report criterion (B) value. Based on SDT convention, a numerically low criterion means a “liberal” tendency to rate most of the stimuli as intense, whereas a numerically high criterion means a “conservative” or “stoic” tendency to label most stimuli as less intense. Therefore, higher (that is, more intense) subject ratings are assigned lower B values and vice versa (fig 22).). Thirdly, the overall report criterion (B) was determined as the B value on the six point rating scale for which half of total responses to both stimulus intensities were to categories above the criterion and half were to categories below the criterion.13
There was a strong correlation between AML pain thresholds and pain report criterion (r=0.67 p<0.0001). On the contrary, AML pain thresholds did not correlate with neurosensory sensitivity for pain (r=−0.13; p=0.14).
The data were not normally distributed. Consequently, non‐parameteric statistical tests were used. Significance was set at a p value of 0.05. Firstly, Wilcoxon rank sum tests were used to compare IBS patients to controls with respect to the following measures: AML determined pain and urge thresholds; SDT determined pain and urge discrimination index (p(A)) and report criterion values (B); BSI anxiety, depression, somatisation, and global severity index scores. Secondly, Spearman correlations were used to determine associations between AML pain thresholds with SDT determined pain discrimination index (p(A)) and report criterion (B). Thirdly, Spearman correlations were used to determine associations between both AML pain thresholds and pain report criteria (B) with the following measures: p(A), BSI anxiety, depression, somatisation, and global severity index scores.
In all, 119 IBS patients and 29 control subjects underwent colonic sensory testing. Of the 13 IBS patients who did not undergo colonic sensory testing, three withdrew consent after the first day, possibly because of apprehension regarding the pain test procedure, three refused flexible sigmoidoscopy, two did not tolerate sigmoidoscopy, one had an extremely elevated blood pressure, and one had colonic inflammation detected on sigmoidoscopy. Of the three excluded control subjects, one did not tolerate the flexible sigmoidoscopy and two had exclusionary medical conditions that were detected during the study (lactose intolerance in one and previous colonic surgery in the other).
On the AML protocol IBS patients had lower pain thresholds (median 28 mmHg vs 40 mmHg; p=0.0002). On sensory decision theory analysis there were no differences in pain neurosensory sensitivity (median p(A): 0.5 vs 0.5; p=0.69; 42.6% of IBS patients vs 42.9% of healthy controls had p(A) >0.5 (chance); p=0.98). Conversely, IBS patients had a lower pain report criterion, which represents their increased tendency to report stimuli as being relatively painful irrespective of the actual intensity of the stimulus (median B: 4.0 (median response = mild pain) vs 5.2 (median response = weak pain); p=0.003) (fig 33).
IBS patients scored higher than controls on all psychometric scales (table 11).). There were modest inverse correlations between pain report criterion (B) and BSI global score (r=−0.18; p=0.035) and BSI somatisation (r=−0.26; p=0.001) (table 22).). Higher psychological distress correlated with an increased tendency to report pain.
Sensory thresholds for urge were lower than those for pain. On the AML protocol IBS patients had lower urge thresholds than controls (median: 18 mmHg vs 34 mmHg; p=0.002), but on sensory decision theory analysis there were no differences in urge neurosensory sensitivity (median p(A): 0.55 vs 0.50; p=0.17; 63.1% of IBS patients vs 46.4% of healthy controls had urge p(A) >0.5 (chance); p=0.10). Conversely, IBS patients had a lower urge report criterion, which represents their increased tendency to report relatively intense urge irrespective of the actual intensity of the stimulus (median B: 3.0 (median response = “moderate” urge) vs 4.2 (median response = “mild”); p=0.006) (fig 44).
There was a strong inverse correlation between AML urge thresholds and urge report criterion (r=−0.51; p<0.0001) and a weaker but significant inverse correlation with neurosensory sensitivity to urge (r=−0.22; p=0.007).
There were modest inverse correlations between urge report criterion (B) and BSI global score (r=−0.19; p=0.03), BSI somatisation (r=−0.18; p=0.04), and BSI anxiety (r=−0.17; p=0.05) (table 33).). Higher psychological distress correlated with an increased tendency to report urge.
There was a moderately strong positive correlation between pain and urge discrimination (p(A)) (r=0.50; p<0.0001). Similarly, there was a moderately strong positive correlation between pain and urge report criteria (B) r=0.44; p<0.0001).
The SDT test involved 24 distensions at pressures, which were painful for most subjects, and consequently some subjects did not complete all trials. The accuracy of discrimination index (p(A)) and report criterion (B) values in subjects who underwent fewer SDT distension trials might have been lower because of increased variance. We therefore excluded subjects who completed fewer than one‐half (<12) of all trials (33 IBS, 4 controls, p=0.158) and repeated the comparison between IBS patients and controls for pain p(A) and report criterion (B). The pattern of results and the significance of the differences did not change for pain p(A) (median p(A) 0.5 vs 0.5; p=0.31; % with pain p(A) > chance: IBS=47.1%; control=41.7%; p=0.63;) or pain report criterion (median B: IBS=4.4; control=5.4; p=0.0001).
Repeated distension of the colon has been previously shown to induce hyperalgesia (“sensitisation”) in IBS patients.8 Thus, it is possible that as a result of this potential sensitisation, the intensity ratings made by IBS patients to late SDT trials may have been affected. In order to test for this we first determined the change in pain intensity ratings between the first and the last 30 mmHg and 34 mmHg trials (change in ratings = pain intensity rating to the last 30 mmHg stimuli plus pain intensity rating to the last 34 mmHg stimuli minus pain intensity ratings to the first 30 mmHg stimuli minus pain intensity rating to the first 34 mmHg stimuli). We then used the Wilcoxon rank sum test of differences to compare change in intensity ratings between IBS patients and controls who completed at least one‐half (12) of all trials. There was no difference between the two groups (p=0.22).
Finally, the intensities of the three SDT stimuli (30 mmHg, 32 mmHg, 34 mmHg) were below AML pain thresholds for some subjects (mostly controls) and above threshold for other subjects (mostly IBS patients). Therefore, it was possible that certain subjects failed to demonstrate discrimination (p(A)) because they assigned the same ratings to all stimuli (either calling all of them “intense” or calling all of them non‐painful). We identified nine (7.4%) IBS patients and nine (35%) healthy controls who rated each SDT stimulus as zero pain intensity. One IBS patient rated all stimuli as “intense.” All other subjects varied their pain intensity ratings. When we excluded the 10 IBS patients and nine healthy controls who did not vary their pain intensity ratings and repeated the analysis, the pattern of results and the significance of the differences did not change for pain p(A) (median p(A) 0.5 vs 0.52; p=0.8); percentage with pain p(A) > chance: IBS=45.6%; control=52.2%; p=0.57) or pain report criterion (median B: IBS=3.9; control=4.52; p=0.04).
In this study we first used AML to measure pain and urge thresholds and we then used SDT to determine the two components of these thresholds: physiologically determined neurosensory sensitivity and psychologically determined report criterion. Using these techniques, we demonstrated that lower AML determined pain and urge thresholds in patients with IBS are explained primarily by an increased tendency to report pain and urge, not increased neurosensory sensitivity. Since this lower report criterion reflects psychological phenomena, increased colonic sensitivity in IBS appears to be determined more by psychological factors than by physiological factors.
Pain is a complex perceptual experience that can only be measured indirectly.21 Gastrointestinal pain sensitivity is typically measured by pain thresholds, which are defined as the lowest stimulus intensity to which subjects report pain. However, pain thresholds are not equivalent with painful sensations since pain reports are influenced by non‐neurosensory factors such as placebo, emotion, attention, and distraction.13
SDT is an alternative pain measurement technique that separately quantifies the individual components of the pain response: neurosensory sensitivity (p(A)), a measure of neurosensory function based on the ability to discriminate between stimuli; and report criterion (B), a measure of stoicism based on the overall tendency to report pain.13 Importantly, previous research has shown that only the criterion is susceptible to changes in cognitive or psychological variables.13,14,15 The discrimination index, p(A), changes in response to analgesic drugs but is not influenced by psychological manipulations.15,16 In this study, IBS patients had similar pain neurosensory sensitivity and lower pain report criterion compared to healthy controls. In other words, their tendency to report pain at lower thresholds related not to increased neural sensitivity, but rather to their predilection towards reporting pain.
Whereas SDT has been widely used in somatic pain research13 it has been used only rarely in previously published studies on visceral pain sensitivity in functional gastrointestinal disorders. Bradley et al observed lower AML pain thresholds, similar neurosensory sensitivity, and decreased report criterion for balloon distensions of the oesophagus in patients with non‐cardiac chest pain,22 which is similar to the findings of this study. Whitehead et al observed lower AML pain thresholds and similar neurosensory sensitivity for rectal distensions in women with IBS,19 which is also similar to the findings of this study. However, they did not measure the report criterion.
Similar to pain, our findings also suggest that lower AML determined urge thresholds in patients with IBS are largely explained by an increased tendency to report urge. However, the finding that urge thresholds and urge neurosensory sensitivity were inversely correlated (r=−0.22, p<0.005) suggests that lower urge thresholds in IBS may also be attributable—albeit to a lesser extent—to increased urge neurosensory sensitivity. These findings contrast with those reported by Corsetti et al who, using non‐painful, barely perceivable balloon distensions, found that patients with IBS had increased neurosensory sensitivity and similar report criterion. However, unlike our study, their study involved a small population (22 patients and 13 controls) in which there were no psychological differences between the IBS and control groups.23
The increased tendency to report pain and urge in patients with IBS may be the downstream result of multiple cognitive and psychological processes. Firstly, patients with IBS appear to be hypervigilant to gastrointestinal sensations.12,24 For example, on functional brain imaging they show similar, abnormal cortical responses to both actual and anticipated (sham) distensions.25,26 Secondly, hypervigilance may reduce the intensity at which they notice gut distensions28 and sensations. Thirdly, once perceived, subjects with IBS interpret these sensations through a generally negative schema (framework for explaining reality),28 which leads them to attribute their sensations to disease.29 Finally, disease attribution in turn further increases attention to gastrointestinal symptoms30 through which a cycle of gastrointestinal sensory amplification is ultimately established.31 Along these lines, in our study somatisation was more common in IBS and was correlated inversely with pain thresholds and directly with the response criterion. This is similar to findings that in Gulf War veterans with IBS, lower pain thresholds could be largely explained by increased somatic focus.32 Other investigators have also found that global psychological distress is correlated with the amount of brain activation in response to painful rectal distension33 and is inversely correlated with tolerance for painful balloon distension of the rectum.34
In order to assess visceral sensitivity independently from these cognitive processes, some have proposed measuring cortical activity during subliminal distensions (that is, not consciously perceived).35,36 Lawal et al used this approach and found increased cortical activation in subjects with IBS. They interpreted this as evidence for neural hypersensitivity that is independent of cognitive input.37 However, it is unclear whether these distensions were truly subliminal since most individuals can perceive distensions as small as 5 mmHg38; the distensions in their study ranged from 10 mmHg to 20 mmHg. Secondly, their observation that cerebral activation in IBS patients did not increase in a positive dose‐response fashion suggests that IBS patients were globally hypersensitive at baseline. This global hypersensitivity was attributed by Naliboff and Mayer to cognitive and psychological processes such as uncertain expectation and hypervigilance, that could not be completely controlled for in the study.39
Although our data demonstrate that psychological phenomena strongly influence pain thresholds, our experimental methods may not have been sensitive enough to detect subtle differences in neurosensory sensitivity. Thus, we cannot rule out the effects of peripheral physiological mechanisms, such as sensitisation of colonic afferent pathways.6,42,43 This afferent hypersensitivity has been credited to inflammation based on evidence that experimentally induced colonic inflammation lowers rectal pain thresholds in animal models.42 Nonetheless, inflammation has not been shown to explain lower thresholds in IBD patients.43,44
Two potential limitations to this study were posed by the repeated balloon distensions required by the SDT protocol. Firstly, certain subjects failed to complete all 24 SDT trials because of intolerable levels of pain or urge. We estimated the effects of this by repeating our analyses without including those subjects who completed fewer than half of the trials. The results were the same. Secondly, the process of repeated very intense colonic distensions (60 mmHg) has been previously shown to induce rectal hypersensitivity in subjects with IBS.8 We estimated the effects of this by comparing the change in pain intensity ratings between early and late stimuli in IBS patients and healthy controls. There was no difference between the two groups.
SDT, which quantifies the ability of subjects to discriminate between very similar stimuli, required that we use stimulus intensities that were very close to each other (30 mmHg vs 34 mmHg). This might have been too close to allow for adequate discrimination—that is, the measurement of neural sensitivity may have been insensitive. However, most subjects can perceive a 5 mmHg increase in stimulus intensity.19 In this study 43% of both IBS patients and healthy controls were able to discriminate between the 30 mmHg and 34 mmHg distensions at better than chance levels (p(A) values above 0.5).
Calculation of the report criterion required us to use the same stimuli for all subjects, irrespective of their AML thresholds. As a result, the ability of some subjects to discriminate between SDT stimuli might have been affected either because the test stimuli were well above their pain threshold or they were so far below their pain threshold that none of them were perceived as painful. We tested for this by excluding subjects who rated all stimuli as equally painful and repeating the analysis. The results did not change. Furthermore, in our previous smaller study where we individualised SDT stimulus intensities for each patient based on their AML determined pain threshold (though we did not compute a report criterion), we still found that subjects with IBS and healthy controls had similar neurosensory sensitivity to pain.19
A theoretical limitation is that we used pressure rather than volume based balloon distensions. Some investigators prefer volume based distensions or indices that integrate pressure and volume into estimates of wall tension.45 We followed the recommendations of an international consensus committee46 by scaling our distensions in pressure rather than volume because it is recognised that volume thresholds are influenced by muscle tone, which varies from hour to hour in response to meal ingestion and anxiety. Individual differences in pain thresholds are believed to be more stable and reproducible when measured on a pressure scale rather than a volume scale.
These data show that lower pain and urge thresholds in subjects with IBS are strongly influenced by cognitive and psychological factors. Peripheral physiological events such as inflammation42 and temporal summation8 have also been shown to influence pain sensitivity. However, these data suggest that, when explaining the differences between IBS patients and healthy controls, the contribution of peripheral physiological events may be relatively small compared to the cognitive and psychological influences that are reflected in the report criterion index, which reflects the generalised tendency to report pain. The implications of this finding are far reaching. Firstly, it underscores the importance of accounting for psychological factors when interpreting tests of sensory function. Secondly, it highlights the important part played by centrally mediated processes in the pathophysiology of visceral sensitivity in IBS and suggests that novel therapies for pain in IBS should target centrally mediated mechanisms.
Supported by grants R24 DK67674, R01 DK31369, RR00046, and T32DK7634 from the National Institutes of Health in the United States.
AML - ascending methods of limits
BSI - Brief Symptom Inventory
IBS - irritable bowel syndrome
IBS‐C - constipation predominant irritable bowel syndrome
IBS‐D - diarrhoea predominant irritable bowel syndrome
IOP - individual operating pressure
ROC - receiver operator characteristic
SDT - sensory decision theory analysis