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Can Med Assoc J. 1970 February 14; 102(3): 263–268.
PMCID: PMC1946394

Treatment of acute otitis media: a controlled study of 142 children


Results of the use of ampicillin, penicillin G and symptomatic therapy in the treatment of acute otitis media in 142 children were compared. Antibiotic therapy conveyed significant benefit. No major differences were observed between penicillin and ampicillin, except in the age group under 3 years where ampicillin was associated with the best results. Ampicillin appears to be the drug of choice. Its superiority over symptomatic therapy was statistically significant. Long-term sequelae were not observed in any of the three treatment groups. The relative merits of erythromycin and ampicillin require further study.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Lenoski EF, Wingert WA, Wehrle PF. Drug trials in acute otitis media. Curr Ther Res Clin Exp. 1968 Dec;10(12):631–639. [PubMed]
  • Roddey OF, Jr, Earle R, Jr, Haggerty R. Myringotomy in acute otitis media. A controlled study. JAMA. 1966 Sep 12;197(11):849–853. [PubMed]

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