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Can Med Assoc J. 1970 August 15; 103(4): 351–356.
PMCID: PMC1930427

The Incidence of Staining of Permanent Teeth by the Tetracyclines

Abstract

In this investigation an attempt has been made to determine the relationship between the staining of permanent teeth by tetracycline administered during the period of tooth formation with the dosage of the drug and the duration of therapy. Of 238 subjects whose hospital records indicated ingestion of stated doses of tetracycline, some 49 were seen to have staining which was confirmed by fluorescence, and a further six had staining which did not fluoresce and hence could not be confirmed. A definite relationship between total dosage and staining and duration of administration and staining was established; the condition occurred with greater frequency (in more than one-third of the children) when the total dosage exceeded 3 g. or the duration of treatment was longer than 10 days. However, as staining was seen at all dosage levels, whatever the duration, physicians should continue to follow previous advice and prescribe other antibiotics where possible for children under 8 years of age or for women in the last trimester of pregnancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • WALLMAN IS, HILTON HB. Teeth pigmented by tetracycline. Lancet. 1962 Apr 21;1(7234):827–829. [PubMed]
  • HARCOURT JK, JOHNSON NW, STOREY E. In vivo incorporation of tetracycline in the teeth of man. Arch Oral Biol. 1962 Jul-Aug;7:431–437. [PubMed]
  • SALTZMAN A. Fluorophotometric estimation of aureomycin in blood and urine. J Lab Clin Med. 1950 Jan;35(1):123–128. [PubMed]
  • MILCH RA, RALL DP, TOBIE JE. Bone localization of the tetracyclines. J Natl Cancer Inst. 1957 Jul;19(1):87–93. [PubMed]
  • GRON P, JOHANNESSEN LB. Fluorescence of tetracycline antibiotics in dentin. Acta Odontol Scand. 1961 May;19:79–85. [PubMed]
  • HILTON HB. Skeletal pigmentation due to tetracycline. J Clin Pathol. 1962 Mar;15:112–115. [PMC free article] [PubMed]
  • FRANKEL MA, HAWES RR. TETRACYCLINE ANTIBIOTICS AND TOOTH DISCOLORATION. J Oral Ther Pharmacol. 1964 Sep;1:147–155. [PubMed]
  • Hennon DK. Dental aspects of tetracycline therapy: literature review and results of a prevalence survey. J Indiana State Dent Assoc. 1965 Dec;44(10):484–492. [PubMed]
  • KUTSCHER AH, ZEGARELLI EV, TOVELL HM, HOCHBERG B. Discoloration of teeth induced by tetracycline administered ante partum. JAMA. 1963 May 18;184:586–587. [PubMed]
  • URIST MR, IBSEN KH. CHEMICAL REACTIVITY OF MINERALIZED TISSUE WITH OXYTETRACYCLINE. Arch Pathol. 1963 Nov;76:484–496. [PubMed]

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