Multiple sequence alignment between Mak11 and putative human (hPip1) and S. pombe
(Skb15) homologues. Sequences of yeast Mak11, S. pombe
Skb15, and human hPip1 were aligned using ClustalW (53
), and similar or identical residues were shaded using BOXSHADE so that residues that have similar properties and are found in all three sequences have a black background while those with similar properties in two out of three sequences have a gray background. The residue changes indicated in the alignment correspond to the observed mutations in the mak11-2
strain. Boxed regions correspond to predicted WD40 motifs.
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