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Scientific investigation is the noblest pursuit. I think we can improve the respect of the public for researchers by showing how difficult success is. Confidence in the research enterprise is probably undermined primarily when we claim that discoveries are more certain than they really are, and then the public, scientists, and patients suffer the painful refutations.
John P. A. Ioannidis (jioannid/at/cc.uoi.gr), University of Ioannina School of Medicine, Ioannina, Epirus, Greece
Funding: The author received no specific funding for this article.
Competing Interests: The author has declared that no competing interests exist.