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Background—Most ulcers are caused, one can deduce,
by Helicobcter pylori or by use of non-steroidal
anti-inflammatory drugs (NSAIDs). Whether both together are worse than
one alone is something that is quite unknown.
Aim—To study both factors in order to see whether they interact together positively.
Method—A case control study of ulcer bleeding in elderly patients chosen without weeding.
Results—NSAID usage increased risk substantially. So did H pylori infection (but relative risk less than three). Neither seemed to interact. Their actions were discretely intact.
Conclusion—H pylori effects ulcer bleeding in an adverse manner but does not make the risk of NSAIDs worse.
Keywords: peptic ulcer; gastric ulcer; duodenal ulcer; haematemesis; melaena; NSAIDs; Helicobacter pylori