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Children aged 2-59 months in Pakistan with “non-severe” pneumonia were randomised to receive a standard dose of amoxicillin (45 mg/kg per day for three days) or double that dose. At follow-up visits at five and 14 days, cumulative therapy failure was 26/437 (6%) in those receiving the standard dose and 35/439 (8%) after a double dose. The difference was non-significant.
Although many cases might have been viral, the World Health Organization recommends using antibiotics in “non-severe” pneumonia in the developing world without trying to discriminate aetiology. This trial suggests that no advantage results from doubling the recommended dose of amoxicillin.