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J Virol. 1995 January; 69(1): 506–508.
PMCID: PMC188599

Congo red prolongs the incubation period in scrapie-infected hamsters.

Abstract

In scrapie-infected cells, Congo red inhibits both the replication of the infectious agent and accumulation of the protease-resistant form of PrP (PrP-res). In this report, we show that Congo red prolongs the incubation periods of hamsters experimentally infected with two different strains of scrapie.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Brown P, Gajdusek DC, Gibbs CJ, Jr, Asher DM. Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy. N Engl J Med. 1985 Sep 19;313(12):728–731. [PubMed]
  • Caughey B, Brown K, Raymond GJ, Katzenstein GE, Thresher W. Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]. J Virol. 1994 Apr;68(4):2135–2141. [PMC free article] [PubMed]
  • Caughey B, Ernst D, Race RE. Congo red inhibition of scrapie agent replication. J Virol. 1993 Oct;67(10):6270–6272. [PMC free article] [PubMed]
  • Caughey B, Race RE, Ernst D, Buchmeier MJ, Chesebro B. Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells. J Virol. 1989 Jan;63(1):175–181. [PMC free article] [PubMed]
  • Caughey B, Raymond GJ. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. J Virol. 1993 Feb;67(2):643–650. [PMC free article] [PubMed]
  • Chesebro B, Race R, Wehrly K, Nishio J, Bloom M, Lechner D, Bergstrom S, Robbins K, Mayer L, Keith JM, et al. Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain. Nature. 1985 May 23;315(6017):331–333. [PubMed]
  • Diringer H, Ehlers B. Chemoprophylaxis of scrapie in mice. J Gen Virol. 1991 Feb;72(Pt 2):457–460. [PubMed]
  • Ehlers B, Diringer H. Dextran sulphate 500 delays and prevents mouse scrapie by impairment of agent replication in spleen. J Gen Virol. 1984 Aug;65(Pt 8):1325–1330. [PubMed]
  • Ehlers B, Rudolph R, Diringer H. The reticuloendothelial system in scrapie pathogenesis. J Gen Virol. 1984 Feb;65(Pt 2):423–428. [PubMed]
  • Farquhar CF, Dickinson AG. Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection. J Gen Virol. 1986 Mar;67(Pt 3):463–473. [PubMed]
  • Gabizon R, Meiner Z, Halimi M, Ben-Sasson SA. Heparin-like molecules bind differentially to prion-proteins and change their intracellular metabolic fate. J Cell Physiol. 1993 Nov;157(2):319–325. [PubMed]
  • Glenner GG. Amyloid deposits and amyloidosis: the beta-fibrilloses (second of two parts). N Engl J Med. 1980 Jun 12;302(24):1333–1343. [PubMed]
  • Kimberlin RH, Walker CA. The antiviral compound HPA-23 can prevent scrapie when administered at the time of infection. Arch Virol. 1983;78(1-2):9–18. [PubMed]
  • Kimberlin RH, Walker CA. Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions. Antimicrob Agents Chemother. 1986 Sep;30(3):409–413. [PMC free article] [PubMed]
  • Ladogana A, Casaccia P, Ingrosso L, Cibati M, Salvatore M, Xi YG, Masullo C, Pocchiari M. Sulphate polyanions prolong the incubation period of scrapie-infected hamsters. J Gen Virol. 1992 Mar;73(Pt 3):661–665. [PubMed]
  • Oesch B, Westaway D, Wälchli M, McKinley MP, Kent SB, Aebersold R, Barry RA, Tempst P, Teplow DB, Hood LE, et al. A cellular gene encodes scrapie PrP 27-30 protein. Cell. 1985 Apr;40(4):735–746. [PubMed]
  • Pocchiari M. Prions and related neurological diseases. Mol Aspects Med. 1994;15(3):195–291. [PubMed]
  • Pocchiari M, Casaccia P, Ladogana A. Amphotericin B: a novel class of antiscrapie drugs. J Infect Dis. 1989 Nov;160(5):795–802. [PubMed]
  • Pocchiari M, Salvatore M, Ladogana A, Ingrosso L, Xi YG, Cibati M, Masullo C. Experimental drug treatment of scrapie: a pathogenetic basis for rationale therapeutics. Eur J Epidemiol. 1991 Sep;7(5):556–561. [PubMed]
  • Pocchiari M, Schmittinger S, Masullo C. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. J Gen Virol. 1987 Jan;68(Pt 1):219–223. [PubMed]
  • Xi YG, Ingrosso L, Ladogana A, Masullo C, Pocchiari M. Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation. Nature. 1992 Apr 16;356(6370):598–601. [PubMed]

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