Search tips
Search criteria 


Logo of aacPermissionsJournals.ASM.orgJournalAAC ArticleJournal InfoAuthorsReviewers
Antimicrob Agents Chemother. Aug 1993; 37(8): 1720–1722.
PMCID: PMC188052
The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase.
J E Wilson, J L Martin, K Borroto-Esoda, S Hopkins, G Painter, D C Liotta, and P A Furman
Division of Virology, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709.
The (-) enantiomer of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine is a potent inhibitor of human immunodeficiency virus type 1 in vitro. The 5'-triphosphates of the (-) and (+) enantiomers equally inhibited the production of full-length minus-strand DNA in an endogenous reverse transcriptase reaction, each competitively inhibited DNA synthesis, and each was used as a chain-terminating substrate.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (851K), or click on a page image below to browse page by page.
Images in this article
Click on the image to see a larger version.
Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of
American Society for Microbiology (ASM)