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Antimicrob Agents Chemother. Aug 1993; 37(8): 1720–1722.
PMCID: PMC188052
The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase.
J E Wilson, J L Martin, K Borroto-Esoda, S Hopkins, G Painter, D C Liotta, and P A Furman
Division of Virology, Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709.
Abstract
The (-) enantiomer of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine is a potent inhibitor of human immunodeficiency virus type 1 in vitro. The 5'-triphosphates of the (-) and (+) enantiomers equally inhibited the production of full-length minus-strand DNA in an endogenous reverse transcriptase reaction, each competitively inhibited DNA synthesis, and each was used as a chain-terminating substrate.
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