Search tips
Search criteria 


Logo of aacPermissionsJournals.ASM.orgJournalAAC ArticleJournal InfoAuthorsReviewers
Antimicrob Agents Chemother. 1993 July; 37(7): 1552–1555.
PMCID: PMC188012

In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and the United States to currently recommended and newer agents for treatment of chancroid.


We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isolates were susceptible to < or = 0.25 microgram of ceftriaxone per ml, < or less 0.5 microgram of cefixime per ml, < or = 0.125 microgram of ciprofloxacin per ml, and < or = 0.06 microgram of ofloxacin per ml. Erythromycin was active against all isolates (MIC for 90% of isolates tested, 0.25 microgram/ml), as was azithromycin (MIC, < or = micrograms/ml). In contrast, all but one isolate were resistant to > or = 8.0 micrograms of tetracycline per ml, 11.1% of the isolates were resistant to and 40.9% of the isolates were resistant to trimethoprim-sulfamethoxazole (MIC, > or = 4/76 microgram/ml.)

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (665K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Abeck D, Johnson AP, Dangor Y, Ballard RC. Antibiotic susceptibilities and plasmid profiles of Haemophilus ducreyi isolates from southern Africa. J Antimicrob Chemother. 1988 Oct;22(4):437–444. [PubMed]
  • Albritton WL, Brunton JL, Slaney L, MacLean I. Plasmid-mediated sulfonamide resistance in Haemophilus ducreyi. Antimicrob Agents Chemother. 1982 Jan;21(1):159–165. [PMC free article] [PubMed]
  • Dangor Y, Miller SD, Exposto F da L, Koornhof HJ. Antimicrobial susceptibilities of southern African isolates of Haemophilus ducreyi. Antimicrob Agents Chemother. 1988 Sep;32(9):1458–1460. [PMC free article] [PubMed]
  • Dylewski J, Nsanze H, D'Costa L, Slaney L, Ronald A. Trimethoprim sulphamoxole in the treatment of chancroid. Comparison of two single dose treatment regimens with a five day regimen. J Antimicrob Chemother. 1985 Jul;16(1):103–109. [PubMed]
  • Girouard YC, Maclean IW, Ronald AR, Albritton WL. Synergistic antibacterial activity of clavulanic acid and amoxicillin against beta-lactamase-producing strains of Haemophilus ducreyi. Antimicrob Agents Chemother. 1981 Jul;20(1):144–145. [PMC free article] [PubMed]
  • Jones BM, Kinghorn GR, Duerden BI. In vitro activity of azithromycin and erythromycin against organisms associated with bacterial vaginosis and chancroid. Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):551–553. [PubMed]
  • Morse SA. Chancroid and Haemophilus ducreyi. Clin Microbiol Rev. 1989 Apr;2(2):137–157. [PMC free article] [PubMed]
  • Motley M, Sarafian SK, Knapp JS, Zaidi AA, Schmid G. Correlation between in vitro antimicrobial susceptibilities and beta-lactamase plasmid contents of isolates of Haemophilus ducreyi from the United States. Antimicrob Agents Chemother. 1992 Aug;36(8):1639–1643. [PMC free article] [PubMed]
  • Sanson-Le Pors MJ, Casin I, Ortenberg M, Perol Y. In-vitro susceptibility of thirty strains of Haemophilus ducreyi to several antibiotics including six cephalosporins. J Antimicrob Chemother. 1983 Mar;11(3):271–280. [PubMed]
  • Sarafian SK, Johnson SR, Thomas ML, Knapp JS. Novel plasmid combinations in Haemophilus ducreyi isolates from Thailand. J Clin Microbiol. 1991 Oct;29(10):2333–2334. [PMC free article] [PubMed]
  • Sarafian SK, Knapp JS. Molecular epidemiology, based on plasmid profiles, of Haemophilus ducreyi infections in the United States. Results of surveillance, 1981-1990. Sex Transm Dis. 1992 Jan-Feb;19(1):35–38. [PubMed]
  • Schmid GP. The treatment of chancroid. JAMA. 1986 Apr 4;255(13):1757–1762. [PubMed]
  • Taylor DN, Pitarangsi C, Echeverria P, Panikabutra K, Suvongse C. Comparative study of ceftriaxone and trimethoprim-sulfamethoxazole for the treatment of chancroid in Thailand. J Infect Dis. 1985 Nov;152(5):1002–1006. [PubMed]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)