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One week of treatment with omeprazole, clarithromycin, and amoxicillin is as effective as two weeks of this treatment in eradicating Helicobacter pylori in patients with duodenal ulcer. This is clear from a double blind, placebo controlled study in more than 900 consecutive patients, based both on intention to treat and per protocol analyses. This triple therapy eradicated the organism in about 80% of patients (compared with just over 40% of those who took only omeprazole and amoxicillin). The one week and two week treatments were similar for safety and compliance.