|Home | About | Journals | Submit | Contact Us | Français|
The following two reviews are part of the symposium on angiogenesis begun in the April 2005 issue of Neuro-Oncology. In the review by Bergers and Song, the authors describe the important role of pericytes in regulating blood vessel maturation and survival, useful markers of pericytes, and the similarity of pericyte function in embryogenesis and tumor angiogenesis. Fig. 1C from this review is the cover photograph for this issue of the journal. It demonstrates the architecture of brain capillaries and highlights the contribution of pericytes, the complex tight junctions of brain capillary endothelial cells, and astrocytic foot processes to the formation of the blood-brain barrier. In the second review by Abounader and Laterra, the authors describe the functional role of scatter factor (SF)/hepatocyte growth factor (HGF) in promoting cell growth, invasion, and angiogenesis in tumors. They discuss published data indicating that SF/HGF levels are signifi cantly elevated in glioblastoma tumors and that SF/HGF can function in both a paracrine and autocrine manner to promote tumorigenicity. SF/HGF synthesized by glioblastoma tumor cells binds to its receptor c-Met on endothelial cells, promoting tubule formation (angiogenesis), and SF/HGF can also bind to c-Met expressed on glioblastoma tumor cells, promoting tumor cell proliferation and invasion. This review suggests that the SF/HGF-c-Met signaling pathway is an important target for new glioblastoma tumor therapies.