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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
Proc R Soc Med. 1961 May; 54(5): 403–405.
PMCID: PMC1869569

The Inhibition of Acetylcholinesterase by Organophosphorus Compounds and its Reversal [Abridged]

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Selected References

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  • ALDRIDGE WN, DAVISON AN. The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. II. Diethyl p-nitrophenyl thionphosphate (E605) and analogues. Biochem J. 1952 Dec;52(4):663–671. [PubMed]
  • ASKEW BM. Oximes and atropine in sarin poisoning. Br J Pharmacol Chemother. 1957 Sep;12(3):340–343. [PubMed]
  • BERRY WK, DAVIES DR, GREEN AL. Oximes of alpha omega-diquaternary alkane salts as antidotes to organophosphate anticholinesterases. Br J Pharmacol Chemother. 1959 Jun;14(2):186–191. [PubMed]
  • DAVIES DR, GREEN AL. The kinetics of reactivation, by oximes, of cholinesterase inhibited by organophosphorus compounds. Biochem J. 1956 Aug;63(4):529–535. [PubMed]
  • ERDMANN WD. [Clinical experiences with the antidote pyridine-2-aldoxime methiodide (PAM) in E 605 poisoning. Selected cases]. Dtsch Med Wochenschr. 1960 Jun 3;85:1014–1016. [PubMed]
  • HOBBIGER F. Chemical reactivation of phosphorylated human and bovine true cholinesterases. Br J Pharmacol Chemother. 1956 Sep;11(3):295–303. [PubMed]
  • HOBBIGER F, PITMAN M, SADLER PW. Reactivation of phosphorylated acetocholinesterases by pyridinium aldoximes and related compounds. Biochem J. 1960 May;75:363–372. [PubMed]
  • HOBBIGER F, SADLER PW. Protection against lethal organophosphate poisoning by quaternary pyridine aldoximes. Br J Pharmacol Chemother. 1959 Jun;14(2):192–201. [PubMed]
  • HOLMES R. Discussion on poisoning with anticholinesterases. Proc R Soc Med. 1953 Oct;46(10):799–800. [PMC free article] [PubMed]
  • KARLOG O, NIMB M, POULSEN E. Parathion (bladan) forgiftning behandlet med 2-PAM (pyridyl-(2)-aldoxim-N-metyliodid). Ugeskr Laeger. 1958 Feb 6;120(6):177–183. [PubMed]
  • KOELLE GB. Histochemical demonstration of reactivation acetylcholinesterase in vivo. Science. 1957 Jun 14;125(3259):1195–1196. [PubMed]
  • NAMBA T, HIRAKI K. PAM (pyridine-2-aldoxime methiodide) therapy for alkyl-phosphate poisoning. J Am Med Assoc. 1958 Apr 12;166(15):1834–1839. [PubMed]
  • RUTLAND JP. The effect of some oximes in sarin poisoning. Br J Pharmacol Chemother. 1958 Dec;13(4):399–403. [PubMed]
  • WILSON IB. Designing of a new drug with antidotal properties against the nerve gas sarin. Biochim Biophys Acta. 1958 Jan;27(1):196–199. [PubMed]

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