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A wide variety of tumours of the brain occur in the dog, most commonly in the Boxer breed. Tumours may arise from the subependymal plate which may influence the parts of the brain destroyed and hence the pattern of clinical signs. Because of the small capacity of the dog's skull, vital neurological structures are quickly destroyed and the time course of these events is much shorter than in man. The high incidence of tumours in the Boxer would suggest that this breed might afford a useful model for clinical treatment using, for instance, cytotoxic agents.