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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
 
Proc R Soc Med. 1976; 69(Suppl 2): 101–103.
PMCID: PMC1864042

Effect of gemfibrozil in vitro on fat-mobilizing lipolysis in human adipose tissue.

Abstract

Fat-mobilizing lipolysis was studied in rat and human adipose tissue during incubation in vitro by following the release of glycerol into the incubation medium. Gemfibrozil as well as clofibrate consistently and readily inhibited basal as well as noradrenaline-stimulated fat-mobilizing lipolysis in rat fat. With human adipose tissue no effect was observed with gemfibrozil and clofibrate on basal lipolysis. This may be due to the comparatively low rate of the nonstimulated fat-mobilizing lipolysis in human tissue incubated in vitro. When lipolysis was stimulated with noradrenaline as well as isoprenaline, however, both gemfibrozil and clofibrate significantly reduced the fat-mobilizing lipolysis. This inhibition of lipolysis was however not observed in all studies. When lipolysis had been stimulated with theophylline, no inhibition of lipolysis was obtained with either compound. The possibility that reduced fat-mobilizing lipolysis in adipose tissue may cause a lowering of plasma triglycerides by reducing the flow of FFA to the liver is discussed in some detail. It is also suggested that inhibition of lipolysis may be accompanied by increased activity of lipoprotein lipase as well as an increase in the FIAT process. However, the pharmacological implication of the above-mentioned findings, particularly for gemfibrozil, must await further studies, as fairly large doses, around 1 mg/ml of incubation medium, were needed to obtain inhibition of fat-mobilizing lipolysis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bizzi A, Carlson LA. Stimulatory effect of ethanol on glycerol release from rat adipose tissue in vitro. Life Sci. 1965 Nov;4(21):2123–2128. [PubMed]
  • CARLSON LA. Studies on the effect of nicotinic acid on catecholamine stimulated lipolysis in adipose tissue in vitro. Acta Med Scand. 1963 Jun;173:719–722. [PubMed]
  • Carlson LA, Walldius G. Fatty acids incorporation into human adipose tissue in hypertriglyceridaemia. Eur J Clin Invest. 1976 Jun 21;6(3):195–211. [PubMed]
  • Carlson LA, Walldius G, Butcher RW. Effect of chlorophenoxyisobutyric acid (CPIB) on fat-mobilizing lipolysis and cyclic AMP levels in rat epididymal fat. Atherosclerosis. 1972 Nov-Dec;16(3):349–357. [PubMed]
  • DUNCAN CH, BEST MM, ROBERTSON GL. A COMPARISON OF THE EFFECTS OF ETHYL CHLOROPHENOXYISOBUTYRATE AND NICOTINIC ACID ON PLASMA FREE FATTY ACIDS. Lancet. 1965 Jan 23;1(7378):191–193. [PubMed]

Articles from Proceedings of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press