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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
 
Proc R Soc Med. 1976; 69(Suppl 2): 94–97.
PMCID: PMC1864040

Lipokinetic studies with gemfibrozil (CI-719).

Abstract

Gemfibrozil (CI-719) has proved to be an effective agent in reducing the plasma triglyceride levels in experimental animals and in patients with endogenous hypertriglyceridaemia. We have confirmed these findings.

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Selected References

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  • Adams PW, Kissebah AH, Harrigan P, Stokes T, Wynn V. The kinetics of plasma free fatty acid and triglyceride transport in patients with idiopathic hypertriglyceridaemia and their relation to carbohydrate metabolism. Eur J Clin Invest. 1974 Jun;4(3):149–161. [PubMed]
  • Barter PJ, Nestel PJ, Carroll KF. Precursors of plasma triglyceride fatty acid in humans. Effects of glucose consumption, clofibrate administration, and alcoholic fatty liver. Metabolism. 1972 Feb;21(2):117–124. [PubMed]
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  • Eisenberg S, Rachmilewitz D. Metabolism of rat plasma very low density lipoprotein. I. Fate in circulation of the whole lipoprotein. Biochim Biophys Acta. 1973 Dec 20;326(3):378–390. [PubMed]
  • Kissebah AH, Adams PW, Harrigan P, Wynn V. The mechanism of action of clofibrate and tetranicotinoylfructose (Bradilan) on the kinetics of plasma free fatty acid and triglyceride transport in type IV and type V hypertriglyceridaemia. Eur J Clin Invest. 1974 Jun;4(3):163–174. [PubMed]
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  • Kissebah AH, Alfarsi S, Adams PW, Seed M, Folkard J, Wynn V. Transport kinetics of plasma free fatty acid, very low density lipoprotein triglycerides and apoprotein in patients with endogenous hypertriglyceridaemia: effects of 2,2-dimethyl, 5(2, 5-xylyoxy) valeric acid therapy. Atherosclerosis. 1976 Jul-Aug;24(1-2):199–218. [PubMed]
  • Kissebah AH, Alfarsi S, Adams PW, Wynn V. The metabolic fate of plasma lipoproteins in normal subjects and in patients with insulin resistance and endogenous hypertriglyceridaemia. Diabetologia. 1976 Oct;12(5):501–509. [PubMed]

Articles from Proceedings of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press