PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
 
Proc R Soc Med. 1976; 69(Suppl 2): 32–37.
PMCID: PMC1864027

Gemfibrozil as a lipid lowering compound in hyperlipoproteinaemia. A placebo-controlled cross-over trial.

Abstract

The efficacy of gemfibrozil in lowering increased serum lipoprotein concentrations was tested in a placebo-controlled cross-over trial on 30 patients. Administered in a dose of 1200 mg daily, gemfibrozil reduced increased serum triglyceride levels by approximately 50% and reduced increased serum cholesterol concentrations by about 20%. Elevated VLDL triglyceride levels were reduced by 60%, and increased LDL cholesterol concentrations were reduced by approximately 20%. The mean HDL cholesterol concentration increased during gemfibrozil treatment. No adverse reactions attributable to gemfibrozil were recorded during the trial.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (846K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Beaumont JL, Carlson LA, Cooper GR, Fejfar Z, Fredrickson DS, Strasser T. Classification of hyperlipidaemias and hyperlipoproteinaemias. Bull World Health Organ. 1970;43(6):891–915. [PubMed]
  • BURSTEIN M, SAMAILLE J. [On a rapid determination of the cholesterol bound to the serum alpha- and beta-lipoproteins]. Clin Chim Acta. 1960 Jul;5:609–609. [PubMed]
  • Lawther PJ, Waller RE. Physical hazards. Postgrad Med J. 1975;51 (Suppl 2):suppl 51–9. [PubMed]
  • HAVEL RJ, EDER HA, BRAGDON JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955 Sep;34(9):1345–1353. [PMC free article] [PubMed]
  • IKKOS D, LUFT R. On the intravenous glucose tolerance test. Acta Endocrinol (Copenh) 1957 Jul;25(3):312–334. [PubMed]
  • Lizana J, Hellsing K. Manual immunoephelometric assay of proteins, with use of polymer enhancement. Clin Chem. 1974 Sep;20(9):1181–1186. [PubMed]
  • Miller GJ, Miller NE. Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet. 1975 Jan 4;1(7897):16–19. [PubMed]
  • Velasco CA, Cole HS, Camerini-Davalos RA. Radioimmunoassay of insulin, with use of an immunosorbent. Clin Chem. 1974 Jun;20(6):700–702. [PubMed]

Articles from Proceedings of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press