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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
Proc R Soc Med. 1975 August; 68(8): 527–528.
PMCID: PMC1863830

Haematoporphyrins in the diagnosis and treatment of carcinoma of the bladder.


The localization of an haematoporphyrin derivative (HpD) was studied in the operative specimens of three patients with carcinoma of the bladder. The drug was found to localize preferentially in malignant and premalignant mucosa and not in normal bladder tissues. It is suggested that HpD fluorescence might be useful as a diagnostic aid and its photosensitizing properties be used as a mode of therapy for carcinoma of the bladder.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Diamond I, Granelli SG, McDonagh AF, Nielsen S, Wilson CB, Jaenicke R. Photodynamic therapy of malignant tumours. Lancet. 1972 Dec 2;2(7788):1175–1177. [PubMed]
  • Kelly JF, Snell ME, Berenbaum MC. Photodynamic destruction of human bladder carcinoma. Br J Cancer. 1975 Feb;31(2):237–244. [PMC free article] [PubMed]
  • Kyriazis GA, Balin H, Lipson RL. Hematoporphyrin-derivative-fluorescence test colposcopy and colpophotography in the diagnosis of atypical metaplasia, dysplasia, and carcinoma in situ of the cervix uteri. Am J Obstet Gynecol. 1973 Oct 1;117(3):375–380. [PubMed]
  • Leonard JR, Beck WL. Hematoporphyrin fluorescence: an aid in diagnosis of malignant neoplasms. Laryngoscope. 1971 Mar;81(3):365–372. [PubMed]
  • LIPSON RL, BALDES EJ, OLSEN AM. The use of a derivative of hematoporhyrin in tumor detection. J Natl Cancer Inst. 1961 Jan;26:1–11. [PubMed]

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