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Logo of procrsmedFormerly medchtJournal of the Royal Society of MedicineProceedings of the Royal Society of Medicine
 
Proc R Soc Med. 1975 March; 68(3): 141–145.
PMCID: PMC1863682

Transmission of human leukaemia to nonhuman primates.

Abstract

The experiments described show that inoculation of two monkey species, M. arctoides and P. hamadryas, with human leukaemic blood or its filtrates causes a viral disease with the characteristics of malignant lymphoma of mixed type. The disease was passed in subsequent passages. The virus was isolated and identified as an oncornavirus of C-type by its characteristic morphological appearance and buoyant density (1.16 g/cm3 in sucrose and 1.21 g/cm3 in caesium chloride), and by the presence of 60-70S RNA and RNA-dependent DNA polymerase. There is some evidence that it differs immunologically from other known oncornaviruses of mammals including primates. It is postulated that both horizontal and vertical transmission of this oncornavirus can occur.

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Selected References

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  • Kokosha LV, Lapin BA, Deichman GI, Iakovleva LA. Ispol'zovanie tests nepriamoi immunofliuorestsentsii pri izuchenii étiologii leikoza cheloveka v éksperimente na obez'ianakh. Vopr Virusol. 1973 Sep-Oct;18(5):582–588. [PubMed]
  • Lapin BA. The epidemiologic and genetic aspects of an outbreak of leukemia among Hamadryas baboons of the Sukhumi monkey colony. Bibl Haematol. 1973;39:263–268. [PubMed]
  • Lapin BA, Iakovleva LA. O virusnoi prirode leikoza cheloveka. Vestn Akad Med Nauk SSSR. 1970 Jan;25(5):60–71. [PubMed]
  • Lapin BA, Iakovleva LA, Asanov NS, Kokosha LV, Tsiripova GS. Epidemiologicheskii aspekt vspyshki leikoza v stade pavianov gamadrilov Sukhumskogo pitomnika. Vopr Virusol. 1973 Jan-Feb;18(1):38–44. [PubMed]
  • Lapin BA, Iakovleva LA, Kuksova MI, Adzhigitov FI, Krivoshein Iu S, Skurkovich SV. Reaktsiia obez'ian na vvedenie im krovi liudei, bol'nykh leikozom (predvaritel'noe soobshchenie) Biull Eksp Biol Med. 1967 Aug;64(8):78–83. [PubMed]
  • Yakovleva LA. Studies on the conjectural virus nature of human leukemia in experiments on monkeys. Bibl Haematol. 1970;(36):761–772. [PubMed]

Articles from Proceedings of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press