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Logo of arthrestherBioMed Centralbiomed central web sitesearchsubmit a manuscriptregisterthis articleArthritis Research & Therapy
Published online 2007 January 23. doi: 10.1186/ar2109

Figure 9

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COX inhibition impairs reverse cholesterol transport. COX-1/2 inhibition downregulates 27-hydroxylase and ABCA1, thereby decreasing cholesterol efflux, in turn promoting the accumulation of cholesterol in macrophages that transform into foam cells. This effect is restored by the addition of prostaglandins. AA, arachidonic acid; ABCA1, ATP-binding cassette transporter A1; COX, cyclooxygenase; PG, prostaglandin; TXA, thromboxane A.

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