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On qualifying, Macpherson Knowles worked at St Thomas's, becoming senior casualty officer. In 1944 he joined the Royal Army Medical Corps and was posted to the Grenadier Guards, serving mainly in Italy and Palestine.
On demobilisation he returned to St Thomas's and then went to Roffey Park. In 1949 he went into general practice in Worcester, where he remained happily until his retirement in 1984. He was a foundation member of the Royal College of General Practitioners, receiving the gold foundation member medal in 2002.
Always an active member of the BMA, he was representative, social secretary, and chairman of the local division, as well as chairman of the local medical committee in 1970.
He was happily married to Joan for 59 years until her death in 2006; he leaves a daughter, a son, and two grand daughters.