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BMJ. 1989 April 8; 298(6678): 920–924.
PMCID: PMC1836205

Plasma cholesterol, coronary heart disease, and cancer in the Renfrew and Paisley survey.


The relation between plasma cholesterol concentration and mortality from coronary heart disease, incidence of and mortality from cancer, and all cause mortality was studied in a general population aged 45-64 living in the west of Scotland. Seven thousand men (yielding 653 deaths from coronary heart disease, 630 new cases of cancer, and 463 deaths from cancer) and 8262 women (322 deaths from coronary heart disease, 554 new cases of cancer, and 395 deaths from cancer) were examined initially in 1972-6 and followed up for an average of 12 years. All cause mortality was not related to plasma cholesterol concentration. This was largely a consequence of a positive relation between cholesterol values and mortality from coronary heart disease being balanced by inverse relations between cholesterol and cancer and between cholesterol and other causes of death. These changes were highly significant for coronary heart disease and cancer in men and significant for coronary heart disease and other causes of death in women. The inverse association between cholesterol concentration and cancer in men was strongest for lung cancer, was not merely a function of the age at which a subject died, was present for the incidence of cancer as well as mortality from cancer, and persisted when new cases or deaths occurring within the first four years of follow up were excluded from the analysis.

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  • Ahrens EH., Jr The diet-heart question in 1985: has it really been settled? Lancet. 1985 May 11;1(8437):1085–1087. [PubMed]
  • Rose G, Shipley M. Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study. Br Med J (Clin Res Ed) 1986 Aug 2;293(6542):306–307. [PMC free article] [PubMed]
  • Martin MJ, Hulley SB, Browner WS, Kuller LH, Wentworth D. Serum cholesterol, blood pressure, and mortality: implications from a cohort of 361,662 men. Lancet. 1986 Oct 25;2(8513):933–936. [PubMed]
  • McMichael AJ, Jensen OM, Parkin DM, Zaridze DG. Dietary and endogenous cholesterol and human cancer. Epidemiol Rev. 1984;6:192–216. [PubMed]
  • Hawthorne VM, Greaves DA, Beevers DG. Blood pressure in a Scottish town. Br Med J. 1974 Sep 7;3(5931):600–603. [PMC free article] [PubMed]
  • Annan W, Isherwood DM. An automated method for the direct determination of total serum cholesterol. J Med Lab Technol. 1969 Jul;26(3):202–211. [PubMed]
  • Isles CG, Walker LM, Beevers GD, Brown I, Cameron HL, Clarke J, Hawthorne V, Hole D, Lever AF, Robertson JW, et al. Mortality in patients of the Glasgow Blood Pressure Clinic. J Hypertens. 1986 Apr;4(2):141–156. [PubMed]
  • Alderson MR, Bayliss RI, Clarke CA, Whitfield AG. Death certification. Br Med J (Clin Res Ed) 1983 Aug 13;287(6390):444–445. [PMC free article] [PubMed]
  • Leren P. The Oslo diet-heart study. Eleven-year report. Circulation. 1970 Nov;42(5):935–942. [PubMed]
  • Turpeinen O, Karvonen MJ, Pekkarinen M, Miettinen M, Elosuo R, Paavilainen E. Dietary prevention of coronary heart disease: the Finnish Mental Hospital Study. Int J Epidemiol. 1979 Jun;8(2):99–118. [PubMed]
  • Canner PL, Berge KG, Wenger NK, Stamler J, Friedman L, Prineas RJ, Friedewald W. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986 Dec;8(6):1245–1255. [PubMed]
  • Blankenhorn DH, Nessim SA, Johnson RL, Sanmarco ME, Azen SP, Cashin-Hemphill L. Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA. 1987 Jun 19;257(23):3233–3240. [PubMed]
  • Westlund K, Nicolaysen R. Ten-year mortality and morbidity related to serum cholesterol. A follow-up of 3.751 men aged 40-49. Scand J Clin Lab Invest Suppl. 1972;127:1–24. [PubMed]
  • Dyer AR, Stamler J, Paul O, Shekelle RB, Schoenberger JA, Berkson DM, Lepper M, Collette P, Shekelle S, Lindberg HA. Serum cholesterol and risk of death from cancer and other causes in three Chicago epidemiological studies. J Chronic Dis. 1981;34(6):249–260. [PubMed]
  • Oliver MF. Anticoagulants after myocardial infarction in the elderly. Lancet. 1981 Jan 10;1(8211):101–102. [PubMed]
  • Thomas CB, Duszynski KR, Shaffer JW. Cholesterol levels in young adulthood and subsequent cancer: a preliminary note. Johns Hopkins Med J. 1982 Mar;150(3):89–94. [PubMed]
  • Hiatt RA, Friedman GD, Bawol RD, Ury HK. Breast cancer and serum cholesterol. J Natl Cancer Inst. 1982 Jun;68(6):885–889. [PubMed]
  • Salonen JT. Risk of cancer and death in relation to serum cholesterol. A longitudinal study in an eastern Finnish population with high overall cholesterol level. Am J Epidemiol. 1982 Oct;116(4):622–630. [PubMed]
  • Beaglehole R, Foulkes MA, Prior IA, Eyles EF. Cholesterol and mortality in New Zealand Maoris. Br Med J. 1980 Feb 2;280(6210):285–287. [PMC free article] [PubMed]
  • Cambien F, Ducimetiere P, Richard J. Total serum cholesterol and cancer mortality in a middle-aged male population. Am J Epidemiol. 1980 Sep;112(3):388–394. [PubMed]
  • Rose G, Shipley MJ. Plasma lipids and mortality: a source of error. Lancet. 1980 Mar 8;1(8167):523–526. [PubMed]
  • Williams RR, Sorlie PD, Feinleib M, McNamara PM, Kannel WB, Dawber TR. Cancer incidence by levels of cholesterol. JAMA. 1981 Jan 16;245(3):247–252. [PubMed]
  • Garcia-Palmieri MR, Sorlie PD, Costas R, Jr, Havlik RJ. An apparent inverse relationship between serum cholesterol and cancer mortality in Puerto Rico. Am J Epidemiol. 1981 Jul;114(1):29–40. [PubMed]
  • Kagan A, McGee DL, Yano K, Rhoads GG, Nomura A. Serum cholesterol and mortality in a Japanese-American population: the Honolulu Heart program. Am J Epidemiol. 1981 Jul;114(1):11–20. [PubMed]
  • Wallace RB, Rost C, Burmeister LF, Pomrehn PR. Cancer incidence in humans: relationship to plasma lipids and relative weight. J Natl Cancer Inst. 1982 Jun;68(6):915–918. [PubMed]
  • Peterson B, Trell E. Premature mortality in middle-aged men: serum cholesterol as risk factor. Klin Wochenschr. 1983 Aug 15;61(16):795–801. [PubMed]
  • Hiatt RA, Fireman BH. Serum cholesterol and the incidence of cancer in a large cohort. J Chronic Dis. 1986;39(11):861–870. [PubMed]
  • Schatzkin A, Hoover RN, Taylor PR, Ziegler RG, Carter CL, Larson DB, Licitra LM. Serum cholesterol and cancer in the NHANES I epidemiologic followup study. National Health and Nutrition Examination Survey. Lancet. 1987 Aug 8;2(8554):298–301. [PubMed]
  • Törnberg SA, Holm LE, Carstensen JM, Eklund GA. Risks of cancer of the colon and rectum in relation to serum cholesterol and beta-lipoprotein. N Engl J Med. 1986 Dec 25;315(26):1629–1633. [PubMed]
  • Kark JD, Smith AH, Hames CG. Serum retinol and the inverse relationship between serum cholesterol and cancer. Br Med J (Clin Res Ed) 1982 Jan 16;284(6310):152–154. [PMC free article] [PubMed]
  • Oliver MF. Reducing cholesterol does not reduce mortality. J Am Coll Cardiol. 1988 Sep;12(3):814–817. [PubMed]
  • Oliver MF. Should we not forget about mass control of coronary risk factors? Lancet. 1983 Jul 2;2(8340):37–38. [PubMed]
  • Bewley Beulah R. Noah ND. Iatrogenic diseases – identification and monitoring. J R Soc Med. 1987 Mar;80(3):187–188. [PMC free article]

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