Growing concern over financial interests in clinical research has provoked greater efforts to identify effective management strategies.1 Among the strategies discussed is the disclosure of financial interests to potential research participants.2 However, there is little guidance available concerning such disclosures.3 The Conflict of Interest Notification Study, funded by the National Heart, Lung, and Blood Institute, was initiated to provide data to Institutional Review Boards (IRBs), conflict of interest committees (COICs), and other policy makers to assist them in deciding how, when, and what to disclose to potential research participants. This effort necessitated developing disclosure language concerning different financial interests commonly found in clinical research. We used qualitative data to develop, evaluate, and improve disclosure statements in an effort to create model language. Specifically, we collected data and feedback from 1) IRB and COIC officials to identify the most relevant financial interests; 2) small groups of people with and without health conditions; 3) individual patients seen in a general medicine primary care clinic; and 4) a multidisciplinary panel of experts. This article presents the model language for disclosing financial interests in written materials and describes the empirical basis and theoretical assumptions used in developing the language. Table 1 summarizes the steps in our development process, which we now review in detail.