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Antimicrob Agents Chemother. Sep 1981; 20(3): 410–414.
PMCID: PMC181711
Metronidazole Metabolism in Cultures of Entamoeba histolytica and Trichomonas vaginalis
Bernard B. Beaulieu, Jr., Martha A. McLafferty, Ronald L. Koch, and Peter Goldman*
Division of Clinical Pharmacology, Department of Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
Charles A. Dana Research Institute and the Harvard Thorndike Laboratory of Beth Israel Hospital, Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215
Acetamide forms from metronidazole in cultures of either Entamoeba histolytica or Trichomonas vaginalis as it does in cultures of bacteria which are susceptible to this drug. Under aerobic conditions, the formation of acetamide is more rapid in a strain of T. vaginalis which is more susceptible to metronidazole. Thus, it appears that the formation of acetamide may be associated with the microbiocidal action of metronidazole.
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