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Excess deaths have occurred among pregnant women during influenza pandemics, but the impact of influenza during nonpandemic years is unclear. We evaluated the impact of exposure during nonpandemic influenza seasons on the rates of hospital admissions and physician visits because of respiratory illness among pregnant women.
We conducted a 13-year (1990–2002) population-based cohort study involving pregnant women in Nova Scotia. We compared rates of hospital admissions and physician office visits because of respiratory illness during the influenza season in each trimester of pregnancy with rates during the influenza season in the year before pregnancy and with rates in non-influenza seasons. Poisson regression analyses were performed to estimate rate ratios and 95% confidence intervals (CIs).
Of 134 188 pregnant women in the study cohort, 510 (0.4%) were admitted to hospital because of a respiratory illness during pregnancy and 33 775 (25.2%) visited their physician for the same reason during pregnancy. During the influenza seasons, the rate ratio of hospital admissions in the third trimester compared with admissions in the year before pregnancy was 7.9 (95% CI 5.0–12.5) among women with comorbidities and 5.1 (95% CI 3.6–7.3) among those without comorbidities. The rate of hospital admissions in the third trimester among women without comorbidities was 7.4 per 10 000 woman-months during the influenza season, compared with 5.4 and 3.1 per 10 000 woman-months during the peri-and non-influenza seasons respectively. Corresponding rates among women with comorbidities were 44.9, 9.3 and 18.9 per 10 000 woman-months. Only 6.7% of women with comorbidities had received influenza immunization.
Our data support the recommendation that pregnant women with comorbidities should receive influenza vaccination regardless of their stage of pregnancy during the influenza season. Since hospital admissions because of respiratory illness during the influenza season were also increased among pregnant women without comorbidities, all pregnant women are likely to benefit from influenza vaccination.
Influenza viruses are the most common cause of serious respiratory illnesses in winter around the world. Incontrovertible evidence showing reductions of influenza-associated morbidity and mortality with influenza immunization in high-risk groups has led to the National Advisory Committee on Immunization in Canada and the Advisory Committee on Immunization Practices in the United States to recommend annual vaccination of adults over the age of 65 years, children 6–23 months of age and all people with high-risk comorbid medical conditions.1,2
Among previously healthy pregnant women, excess deaths were documented during the influenza pandemics of 1918/19 and 1957/58.3,4 In both pandemics, pneumonia was reported in 50% of the cases involving pregnant women and was associated with a maternal mortality rate of 50% and a high rate of pregnancy loss (52% in 1918/19). Although fatal and near-fatal influenza has been reported in pregnant women during intra-pandemic influenza seasons,5–7 the true impact of influenza on pregnant women during nonpandemic influenza seasons is not clear. Neuzil and colleagues conducted a 19-year retrospective cohort study in a Tennessee Medicaid population and found an increased risk of hospital admission during the influenza seasons in all trimesters of pregnancy.8 On the basis of documented maternal morbidity and mortality during influenza pandemics and the data reported by Neuzil and colleagues about the increased risk of hospital admission among healthy pregnant women during nonpandemic influenza seasons,8 the US Advisory Committee on Immunization Practices expanded its recommendation for influenza immunization in 2004 to include all women who will be pregnant during an influenza season, regardless of their stage of pregnancy.2 In Canada, the National Advisory Committee on Immunization continues to recommend influenza vaccine for pregnant women if they have medical comorbidities known to place them at increased risk of influenza-associated complications, they are a household contact of a person at high-risk or they will deliver during an influenza season and thus become a household contact of a high-risk newborn.1
Existing studies demonstrating an increased risk of hospital admission among pregnant women during influenza seasons are limited by study design and generalizability.5–10 These limitations identify a need for robust, population-based data on which to base public health policy for influenza immunization during pregnancy. We conducted a population-based study to determine whether the rates of hospital admissions and physician office visits because of respiratory illness among pregnant women with and without medical comorbidities differ between influenza, peri-influenza and non-influenza seasons and between these seasons and the year before pregnancy.
We conducted a population-based retrospective cohort study using the Nova Scotia Atlee Perinatal Database (NSAPD). The cohort comprised all Nova Scotia residents who delivered an infant weighing 500 g or more or who delivered at 20 weeks' gestation or later between Jan. 1, 1990, and Dec. 31, 2002. Information on dates of each trimester of pregnancy and on pre-existing risk factors for severe influenza (e.g., asthma and cardiovascular disease) was obtained from the NSAPD. The NSAPD contains extensive information related to maternal medical conditions, maternal risk factors and demographic factors, the prenatal period, labour and delivery factors and neonatal outcomes for all hospital deliveries among Nova Scotia residents. Data are abstracted from medical records by trained health records personnel using standardized data collection forms. An on-going data quality assurance program, which includes periodic data re-abstraction studies, indicates that the data are reliable.11
Our primary outcome measures — hospital admissions and physician office visits because of respiratory illness — were determined from the Canadian Institute for Health Information's Discharge Abstract Database (hospital admissions) and the Nova Scotia Medical Services Insurance Database (physician office visits). These databases capture all uses of the formal public health care system in Nova Scotia. There is no parallel private system in the province. In addition, a master registration file tracks individuals moving into, and out of, the province by their enrolment in the Nova Scotia Health Services Program. We estimated socioeconomic status from data in the Family Benefits Database, which records receipt of financial support through assistance programs of the provincial and federal governments on a yearly basis. The administrative databases were successfully linked to the NSAPD for 96% of the women in the cohort. The individual categories of respiratory conditions and the corresponding International Classification of Diseases (ICD) codes that we used to identify hospital admissions and physician visits of interest are shown in Appendix 1 (available online at www.cmaj.ca/cgi/content/full/176/4/463/DC1). The ICD codes selected were adapted from those used by Neuzil and colleagues8 except for the code for asthma and the codes for respiratory conditions related to occupational exposures. To be conservative, we chose not to include asthma as a respiratory condition because not all exacerbations of asthma are due to influenza, and any cases of asthma that are due to influenza most likely would have an accompanying influenza-related code on the record.
We obtained information on the defined periods of influenza season from the Nova Scotia Department of Health for the study years (1990–2002). For the purposes of our study, the beginning of the influenza season was defined as the time when 2 or more isolates of influenza were identified in Nova Scotia in sequential weeks or 3 or more isolates were identified in a single week. The end of the influenza season was defined as the time when no influenza isolates were identified in the province in 2 or more sequential weeks unless the lapse was followed by a large number of isolates. The peri-influenza season was defined as the period between Nov. 1 and the start of the influenza season and the 2-week period following influenza season. The non-influenza season was defined as the end of the peri-influenza season until Oct. 31. Data from the Medical Services Insurance Database for October 1999 onward include a code for influenza vaccination; therefore, after this date, we were able to examine the rates of influenza vaccination administered in physician's offices.
Pregnant women were stratified according to the presence or absence of any of the following pre-existing conditions (all information obtained from the NSAPD): pre-existing diabetes, pulmonary disease (including asthma), heart disease, renal disease, and anemia (hemoglobin < 10 g) during the pregnancy. Women with 1 or more of these conditions were defined as having comorbidities. All other women were defined as having no comorbidities.
Trimesters were determined by the date of the birth and gestational age at the time of birth. Gestational age was assigned using last menstrual period, if known, or a clinical estimate of gestational age based on examination of the newborn. If both of these estimates of gestational age were missing, we imputed gestational age using the approach used by Neuzil and colleagues8 (gestational age calculated as the median gestational age for infants born in the same birth year and whose birth weight was within the same 500-g category). Gestational age was imputed for less than 2% of the infants.
We based rates of hospital admissions on the date of admission minus 4 days to attribute the event to the influenza season during which most of the exposure occurred. To be conservative, admissions that resulted in a delivery and during which a respiratory illness was diagnosed were not counted in the rate, and only the first non-delivery-related hospital admission because of a respiratory illness was considered.
Person-time analyses were conducted for the entire pregnancy and by trimester. The number of events (hospital admissions or physician office visits) that occurred during the influenza, peri-influenza and non-influenza seasons was divided by the woman-months in each season to determine the event rate for each of the 3 defined seasons. For the trimester-specific analyses, the number of events and woman-months were further divided into the amount of time a woman spent in each influenza season during each trimester. Poisson regression models were used to adjust for confounding factors, and rate ratios (and 95% confidence intervals [CIs]) were calculated. Potential confounders included maternal age, maternal smoking status, socioeconomic status (based on receipt of family benefits), and number and ages of other children in the home. Since the outcomes for women with more than one pregnancy during the study period are not independent, generalized estimating equations were used to generate unbiased standard errors and 95% CIs.12
Initially, we calculated unadjusted rate ratios. The potential confounding factors were entered into the model, with season as the independent variable of interest. Each potential confounding factor was removed, one at a time, and the model rerun. If removing the factor did not change the coefficient (for season) by 5% or more, the factor was removed and the process repeated. A change of 5% or more was chosen so that factors would be included in the final model if they produced a modest change in the coefficient for season. With this approach, the final model included factors that confounded the relation between season and rates of hospital admission.
Rates of hospital admissions (and physician office visits) during the influenza, peri-influenza and non-influenza seasons for each trimester of pregnancy were compared with rates of admissions (and physician visits) during these 3 seasons in the year before pregnancy for the same cohort of women. In addition, rates of hospital admissions (and physician visits) for each trimester of pregnancy during the influenza and peri-influenza seasons were compared with rates for each trimester during the non-influenza season.
Influenza-attributable risks in each trimester of pregnancy were estimated by subtracting the rate of hospital admissions during the peri-influenza and non-influenza seasons from the rate during the influenza season, as described by Neuzil and colleagues.8 We used the rates of hospital admissions during the peri-influenza season to determine the baseline risk to help quantify the risks specific to influenza-related complications rather than to complications that may be related to other viruses (e.g., respiratory syncytial virus).
This study received approval from the Research Ethics Board of the IWK Health Centre.
There were 134 188 pregnant women in the study cohort. Overall, 13 499 (10.1%) of these women had a medical comorbidity that put them at increased risk of influenza-associated morbidity; of them, 94.5% had just 1 high-risk condition (Table 1). Asthma and anemia were the most common conditions, present in 5.2% and 3.0% of the women respectively. A total of 510 women (0.4%) were admitted to hospital during pregnancy because of a respiratory illness (during any season), and 33 775 (25.2%) visited their physician at least once during pregnancy for the same reason (during any season).
For women with and without comorbidities, the rate ratios of hospital admissions during the influenza season were higher in all trimesters of pregnancy than in the year before pregnancy (Table 2). This difference was most evident among pregnant women with comorbidities, in whom there was an excess of 39.2 hospital admissions per 10 000 woman-months in the third trimester compared with the year before pregnancy (rate ratio 7.9; 95% CI 5.0–12.5). Even among women without comorbidities, there was an excess of 6.0 hospital admissions in the third trimester per 10 000 woman-months during the influenza season compared with the admissions during the influenza season in the year before pregnancy (rate ratio 5.1; 95% CI 3.6–7.3). Adjustment for potential confounders, including socioeconomic status, did not change the rate ratio estimates, and these confounders were therefore not included in the final model.
When we compared rates of hospital admissions by trimester between the influenza and non-influenza seasons, we observed higher rates during the influenza season among both women with and those without comorbidities in all trimesters (Table 3). The rate of hospital admissions was highest in the third trimester, particularly among women with comorbidities. The rate ratio of admissions in the third trimester during the influenza season compared with third-trimester admissions during the non-influenza season was 2.4 among women with comorbidities (95% CI 1.6–3.6); the rate ratio was similarly increased among women without comorbidities (rate ratio 2.4; 95% CI 1.7–3.4).
The rates of hospital admissions increased as pregnancy progressed, even when no influenza activity was detected in the community (Table 3). This increase occurred predominantly among women with comorbidities, among whom the rates of admissions during the non-influenza season were on average 6-fold higher than those among women without comorbidities.
Among women without comorbidities, the rate of physician office visits during the influenza season did not differ significantly during pregnancy from the rate in the year before pregnancy (Table 4). However, among women with comorbidities, the rate of physician visits during the influenza season was 20% higher in the third trimester than in the year before pregnancy. Compared with rates in the non-influenza and peri-influenza seasons, rates of physician visits were higher during the influenza season in all trimesters among women with and without comorbidities (data not shown).
During the years for which immunization data were available, we observed that 2.6% of the women in the study cohort and 6.7% of those with a comorbidity had received an influenza vaccine during pregnancy. These data represent immunizations in physicians' offices and therefore may underrepresent the number of women who were immunized.
This study provides robust, population-based data showing that women at all stages of pregnancy are at increased risk of serious respiratory illness during the influenza season, even in the absence of pre-existing comorbid conditions known to increase the risk of influenza-associated morbidity. Among the women in our cohort who had no comorbidities, the rate of third-trimester hospital admissions during the influenza season was 5 times higher than the rate during the influenza season in the year before pregnancy and more than twice as high as the rate during the non-influenza season. Among the women with comorbidities, the risk of respiratory illness during the influenza season increased markedly as pregnancy progressed but was substantial in all trimesters. In the third trimester, the excess of hospital admissions observed during the influenza season compared with admissions during the peri-influenza season was 35.6 per 10 000 woman-months among women with comorbidities and 2.0 per 10 000 woman-months among women without comorbidities. Given that the influenza season in Nova Scotia lasted 3.4 months on average over the study period, this represents an excess of 1210 hospital admissions in the third trimester per 100 000 pregnant women with comorbidities and 68 per 100 000 without comorbidities.
To put our data into context, the rate of excess hospital admissions that we observed during the influenza season among healthy pregnant women in their third trimester (68 per 100 000) is lower than that reported among healthy children less than 2 years of age (90–1038 per 100 000)13–16 but is comparable to observed rates among American adults aged 15–44 years with comorbid conditions (56–110 per 100 000),17 a group for whom annual influenza immunization is already recommended.1,2,18,19
Although our study involved women from a single Canadian province, the sample was large and incorporated a cohort of pregnant women over a study period of 13 years. This population is similar to the general Canadian population of pregnant women and that of pregnant women in other industrialized nations and is more representative than the Tennessee Medicaid population in the study by Neuzil and colleaegues.8
Patterns of hospital admission rates in our study were similar to those reported by Neuzil and colleagues;8 however, the actual rates were considerably lower in our study, among both women with and those without comorbidities, during all trimesters of pregnancy and among women in the year before they were pregnant. The proportion of women with comorbidities was similar in both studies (about 10%), with chronic pulmonary disease being the most prevalent risk factor in both populations. The observed differences in hospital admission rates between the 2 studies may have been due in part to differences in the ascertainment of study outcomes. To be conservative, we excluded hospital admissions that resulted in delivery as well as admissions because of exacerbated asthma in which no influenza-specific ICD code was identified. Dissimilarity in access to care may also have contributed to the differences in admission rates, since income distribution and universal access to publicly funded health care are the most striking differences between our study population and the Medicaid population studied by Neuzil and colleagues. Populations with an unequal distribution of income are known to experience worse health outcomes and increased mortality than populations in which income distribution is more homogeneous.20–27 Adjustment for family income support did not alter the magnitude of the rate ratios observed in our study.
Inactivated influenza vaccine has a long track record of use in pregnant women and is considered safe in all stages of pregnancy.1,2,28–34 Antibody responses to influenza vaccine have been reported to be similar among pregnant and nonpregnant women.29,30,34 However, vaccine effectiveness has been more difficult to demonstrate because of low immunization rates among pregnant women.8,28–35 In our study, only 2.6% of all pregnant women and 6.7% of pregnant women with a comorbid condition were immunized.
In conclusion, our study provides robust, population-based data showing that all pregnant women are at increased risk of influenza-associated respiratory illness. Concerted efforts should be made to ensure communication of the risks of influenza during pregnancy to women and their health care providers to ensure that all pregnant women have the opportunity to benefit from influenza immunization. Future studies should examine the cost-effectiveness of implementing a publicly funded influenza immunization program for all pregnant women and should include costs associated with hospital admissions and outpatient physician visits as well as broader societal costs.
We thank the Reproductive Care Program of Nova Scotia and the Population Health Research Unit at Dalhousie University for facilitating access to the data.
This article has been peer reviewed.
Contributors: Linda Dodds, Shelly McNeil and Noni MacDonald conceived the project and developed the protocol. Linda Dodds and Shelly McNeil were the principal investigators for the study and wrote the first draft of the manuscript. Deshayne Fell contributed to the development of the analysis plan and analyzed the data. Victoria Allen contributed expertise in maternal and fetal outcomes and assisted in the development of the protocol and data analysis. Ann Coombs and Jeffrey Scott contributed expertise in determining influenza seasons and assisted in the development of the protocol and the interpretation of data. Noni MacDonald contributed to the development of the protocol and analysis plan, and the interpretation and dissemination of data. All of the authors helped draft the manuscript and approved the version to be published.
This study was funded by a grant from the Canadian Institutes of Health Research. Linda Dodds, Shelly McNeil and Victoria Allen are supported by Clinical Research Scholar Awards from Dalhousie University and Dodds and Allen are supported by New Investigator Awards of the Canadian Institutes of Health Research. Although this research is based in part on data obtained from the Population Health Research Unit, the observations and opinions expressed are those of the authors and do not represent those of the Population Health Research Unit.
Competing interests: None declared for Linda Dodds, Deshayne Fell, Victoria Allen and Ann Coombs. Shelly McNeil is a member of the Canadian National Advisory Committee on Immunization. At the time of writing, Noni MacDonald was Acting Editor-in-Chief of CMAJ, and Jeffrey Scott was a member of the Interim Editorial Board of CMAJ.
Correspondence to: Dr. Linda Dodds, Departments of Obstetrics and Gynaecology and of Pediatrics, Perinatal Epidemiology Research Unit, IWK Health Centre, 5850/5980 University Ave., PO Box 9700, Halifax NS B3K 6R8; email@example.com