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Arch Dis Child. 1991 October; 66(10): 1242–1244.
PMCID: PMC1793511

Herpes simplex encephalitis with relapse.


Three children are described in whom herpes simplex encephalitis (HSE) followed a clearly biphasic course. The secondary deterioration may be due to a resurgence of the viral infection and calls into question the adequacy of current treatment regimens for HSE. Alternatively, a postinfectious neuroallergic process may be active in which case immunomodulatory treatment might be more appropriate than further antiviral treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Davis LE, McLaren LC. Relapsing herpes simplex encephalitis following antiviral therapy. Ann Neurol. 1983 Feb;13(2):192–195. [PubMed]
  • Dix RD, Baringer JR, Panitch HS, Rosenberg SH, Hagedorn J, Whaley J. Recurrent herpes simplex encephalitis: recovery of virus after Ara-A treatment. Ann Neurol. 1983 Feb;13(2):196–200. [PubMed]
  • VanLandingham KE, Marsteller HB, Ross GW, Hayden FG. Relapse of herpes simplex encephalitis after conventional acyclovir therapy. JAMA. 1988 Feb 19;259(7):1051–1053. [PubMed]
  • Abramson JS, Roach ES, Levy HB. Postinfectious encephalopathy after treatment of herpes simplex encephalitis with acyclovir. Pediatr Infect Dis. 1984 Mar-Apr;3(2):146–147. [PubMed]
  • Barthez MA, Billard C, Santini JJ, Ruchoux MM, Grangeponte MC. Relapse of herpes simplex encephalitis. Neuropediatrics. 1987 Feb;18(1):3–7. [PubMed]
  • Maxwell GM, Thong YH, Manson JI, Robertson CF. Herpes simplex encephalitis: treatment with adenine arabinoside and cytosine arabinoside. Med J Aust. 1978 Feb 25;1(4):181–183. [PubMed]

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