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Arch Dis Child. 1991 November; 66(11): 1291–1295.
PMCID: PMC1793274

Maternal and fetal influences on blood pressure.

Abstract

To study maternal and fetal influences on blood pressure in childhood 405 children aged 4 years who were born and still resident in the Salisbury health district were visited at home for blood pressure and growth measurements. Information on the pregnancy, delivery, and baby was abstracted from the routine obstetric notes. Similar to recent findings in adults, the child's systolic pressure was inversely related to birth weight and positively related to placental weight. Systolic pressure at 4 years increased by 1.2 mm Hg for every SD decrease in the ratio of head circumference to length at birth, and by 1.1 mm Hg for every SD decrease in ponderal index at birth. Mothers whose haemoglobin concentrations fell below 100g/l during pregnancy had children whose systolic pressures were on average 2.9 mm Hg higher than the children of mothers with higher haemoglobin concentrations. Patterns of placental weight, birth weight, head circumference, and length that are associated with high blood pressure in adults are also associated with higher blood pressure in 4 year old children. Identification of the intrauterine influences that lead to these patterns of fetal growth could lead to the primary prevention of hypertension.

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Selected References

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  • Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989 Mar 4;298(6673):564–567. [PMC free article] [PubMed]
  • Barker DJ, Bull AR, Osmond C, Simmonds SJ. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990 Aug 4;301(6746):259–262. [PMC free article] [PubMed]
  • de Swiet M, Fayers PM, Shinebourne EA. Blood pressure in four and five-year-old children: the effects of environment and other factors in it's measurement--the Brompton study. J Hypertens. 1984 Oct;2(5):501–505. [PubMed]
  • Whincup PH, Cook DG, Shaper AG. Early influences on blood pressure: a study of children aged 5-7 years. BMJ. 1989 Sep 2;299(6699):587–591. [PMC free article] [PubMed]
  • Voors AW, Webber LS, Frerichs RR, Berenson GS. Body height and body mass as determinants of basal blood pressure in children--The Bogalusa Heart Study. Am J Epidemiol. 1977 Aug;106(2):101–108. [PubMed]
  • Gerson LW, Fodor JG. Family aggregation of high blood-pressure groups in two Newfoundland communities. Can J Public Health. 1975 Jul-Aug;66(4):294–298. [PubMed]
  • De Leeuw NK, Lowenstein L, Hsieh YS. Iron deficiency and hydremia in normal pregnancy. Medicine (Baltimore) 1966 Jul;45(4):291–315. [PubMed]
  • Beischer NA, Sivasamboo R, Vohra S, Silpisornkosal S, Reid S. Placental hypertrophy in severe pregnancy anaemia. J Obstet Gynaecol Br Commonw. 1970 May;77(5):398–409. [PubMed]
  • Whincup PH, Cook DG, Shaper AG, Macfarlane DJ, Walker M. Blood pressure in British children: associations with adult blood pressure and cardiovascular mortality. Lancet. 1988 Oct 15;2(8616):890–893. [PubMed]

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