PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of archdischArchives of Disease in ChildhoodVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Arch Dis Child. 1989 April; 64(4): 557–562.
PMCID: PMC1791997

Minor congenital anomalies and ataxic cerebral palsy.

Abstract

The incidence of minor congenital anomalies was examined in 36 patients with ataxic cerebral palsy, in unaffected family members, and in 100 unrelated control subjects. None of the control subjects or family members had more than four anomalies, and 25 of 36 (69%) of the patients had more than four. The distribution of anomalies differed considerably, with 60% of the index cases having seven or more, and 94% of the controls having three or less. The number occurring in the patients was significantly more than in their relatives. Of the 25 patients with more than four anomalies, 16 (64%) had undergone potentially adverse perinatal or early postnatal events. Thus minor congenital anomalies were considerably more frequent in those with ataxic cerebral palsy than in related or unrelated control subjects. These anomalies may be markers of early prenatal factors that contributed to the adverse outcome either directly or by predisposing to perinatal difficulties.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (762K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • MARDEN PM, SMITH DW, MCDONALD MJ. CONGENITAL ANOMALIES IN THE NEWBORN INFANT, INCLUDING MINOR VARIATIONS. A STUDY OF 4,412 BABIES BY SURFACE EXAMINATION FOR ANOMALIES AND BUCCAL SMEAR FOR SEX CHROMATIN. J Pediatr. 1964 Mar;64:357–371. [PubMed]
  • Hook EB, Marden PM, Reiss NP, Smith DW. Some aspects of the epidemiology of human minor birth defects and morphological variants in a completely ascertained newborn population (Madison study). Teratology. 1976 Feb;13(1):47–55. [PubMed]
  • SMITH DW, BOSTIAN KE. CONGENITAL ANOMALIES ASSOCIATED WITH IDIOPATHIC MENTAL RETARDATION. J Pediatr. 1964 Aug;65:189–196. [PubMed]
  • Neuhäuser G, Vogl J. Minor craniofacial anomalies in children. Comparative study of a qualitative and quantitative evaluation. Eur J Pediatr. 1980 May;133(3):243–250. [PubMed]
  • Arima M, Komiya K, Ono K, Hisada K. Congenital minor anomalies in mentally retarded children. Proc Aust Assoc Neurol. 1968;5(1):177–182. [PubMed]
  • Sanner G, Hagberg B. 188 cases of non-progressive ataxic syndromes in childhood. Aspects of aetiology and classification. Neuropadiatrie. 1974 Aug;5(3):224–235. [PubMed]
  • BAX MC. TERMINOLOGY AND CLASSIFICATION OF CEREBRAL PALSY. Dev Med Child Neurol. 1964 Jun;6:295–297. [PubMed]
  • Stanley FJ. An epidemiological study of cerebral palsy in Western Australia, 1956-1975. I: Changes in total incidence of cerebral palsy and associated factors. Dev Med Child Neurol. 1979 Dec;21(6):701–713. [PubMed]
  • Feingold M, Bossert WH. Normal values for selected physical parameters: an aid to syndrome delineation. Birth Defects Orig Artic Ser. 1974;10(13):1–16. [PubMed]
  • Smith DW. Origin and relevance of aberrant scalp and upper facial hair patterning. Birth Defects Orig Artic Ser. 1975;11(7):207–212. [PubMed]
  • Nelson KB, Ellenberg JH. Antecedents of cerebral palsy. Multivariate analysis of risk. N Engl J Med. 1986 Jul 10;315(2):81–86. [PubMed]
  • Paneth N. Birth and the origins of cerebral palsy. N Engl J Med. 1986 Jul 10;315(2):124–126. [PubMed]
  • Ishikawa T, Ogawa Y, Kanayama M, Wada Y. Long-term prognosis of asphyxiated full-term neonates with CNS complications. Brain Dev. 1987;9(1):48–53. [PubMed]
  • Crane J, Anderson B, Marshall R, Harvey P. Subsequent physical and mental development in infants with positive contraction stress tests. J Reprod Med. 1981 Mar;26(3):113–118. [PubMed]
  • Hensleigh PA, Fainstat T, Spencer R. Perinatal events and cerebral palsy. Am J Obstet Gynecol. 1986 May;154(5):978–981. [PubMed]
  • Lindahl E, Michelsson K. Neurodevelopmental significance of minor and major congenital anomalies in neonatal high risk children. Neuropediatrics. 1986 May;17(2):86–93. [PubMed]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Group