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Can Vet J. 1980 March; 21(3): 82–84.
PMCID: PMC1789687

Levamisole Reduces the Thrombocytopenia Associated with Myxovirus Vaccination

Abstract

Mature dogs were vaccinated with a myxovirus vaccine. At this time, half of the dogs were also given a subcutaneous injection of levamisole hydrochloride (2.2 mg/kg). Blood platelets were counted daily. The dogs that had received only the vaccine showed, after 48 hours, a 48% decrease in platelets. Levamisole reduced the thrombocytopenia associated with myxovirus vaccination. Levamisole could have a protective effect on platelets by preventing their aggregation induced by viral neuraminidase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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  • Symoens J, Rosenthal M. Levamisole in the modulation of the immune response: the current experimental and clinical state. J Reticuloendothel Soc. 1977 Mar;21(3):175–221. [PubMed]
  • Turpie AG, Chernesky MA, Larke RP, Packham MA, Mustard JF. Effect of Newcastle disease virus on human or rabbit platelets. Aggregation and loss of constituents. Lab Invest. 1973 May;28(5):575–583. [PubMed]

Articles from The Canadian Veterinary Journal are provided here courtesy of Canadian Veterinary Medical Association