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Infect Dis Obstet Gynecol. 2002; 10(3): 159–160.
PMCID: PMC1784611

Varicella vaccination during early pregnancy: a cause of in utero miliary fetal tissue calcifications and hydrops?


BACKGROUND: It is the purpose of this article to describe a suspected association of inadvertent vaccination with varicella vaccine during early pregnancy with the subsequent development of in utero miliary fetal tissue calcifications and fetal hydrops detected by sonogram at 15 weeks of gestation. CASE: This is a case presentation of a pregnant patient who received varicella vaccination during the same menstrual cycle that she became pregnant, and is supplemented by a literary review. The fetus developed miliary fetal tissue calcifications and fetal hydrops detected by a targeted sonogram at 15 weeks gestation. CONCLUSION: Varicella vaccination during early pregnancy may be a cause of miliary fetal tissue calcifications and fetal hydrops.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Hartung J, Enders G, Chaoui R, Arents A, Tennstedt C, Bollmann R. Prenatal diagnosis of congenital varicella syndrome and detection of varicella-zoster virus in the fetus: a case report. Prenat Diagn. 1999 Feb;19(2):163–166. [PubMed]
  • Mustonen K, Mustakangas P, Valanne L, Professor MH, Koskiniemi M. Congenital varicella-zoster virus infection after maternal subclinical infection: clinical and neuropathological findings. J Perinatol. 2001 Mar;21(2):141–146. [PubMed]

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