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Logo of arthrestherBioMed Centralbiomed central web sitesearchsubmit a manuscriptregisterthis articleArthritis Research & Therapy
 
Arthritis Res Ther. 2006; 8(4): R97.
Published online Jun 15, 2006. doi:  10.1186/ar1974
PMCID: PMC1779415
The MHC2TA -168A>G gene polymorphism is not associated with rheumatoid arthritis in Austrian patients
Babak Yazdani-Biuki,1 Kerstin Brickmann,1 Klaus Wohlfahrt,1 Thomas Mueller,1 Winfried März,2 Wilfried Renner,2 Manuela Gutjahr,2 Uwe Langsenlehner,3 Peter Krippl,3 Thomas C Wascher,4 Bernhard Paulweber,5 Winfried Graninger,1 and Hans-Peter Brezinschekcorresponding author1
1Department of Internal Medicine, Division of Rheumatology, Medical University Graz, Austria
2Clinical Institute of Medical and Laboratory Diagnostics, Medical University Graz, Austria
3Department of Internal Medicine, Division of Oncology, Medical University Graz, Austria
4Department of Internal Medicine, Diabetes and Metabolism Clinic, Medical University Graz, Austria
5Department of Internal Medicine, Landeskrankenanstalten Salzburg, Salzburg, Austria
corresponding authorCorresponding author.
Babak Yazdani-Biuki: babak.yazdanibiuki/at/meduni-graz.at; Kerstin Brickmann: kebrick/at/gmx.at; Klaus Wohlfahrt: Klaus.wohlfahrt/at/gmx.at; Thomas Mueller: thomas.mueller/at/meduni-graz.at; Winfried März: winfried.maerz/at/klinikum-graz.at; Wilfried Renner: wilfried.renner/at/klinikum-graz.az; Manuela Gutjahr: manuella.gutjahr/at/klinikum-graz.at; Uwe Langsenlehner: uwe.langsenlehner/at/klinikum-graz.at; Peter Krippl: peter.krippl/at/klinikum-graz.at; Thomas C Wascher: thomas.wascher/at/meduni-graz.at; Bernhard Paulweber: Bernhard.paulweber/at/sbg.at; Winfried Graninger: winfried.graninger/at/meduni-graz.at; Hans-Peter Brezinschek: hans-peter.brezinsek/at/meduni-graz.at
Received February 23, 2006; Revisions requested April 6, 2006; Revised May 8, 2006; Accepted May 17, 2006.
Abstract
An association between susceptibility to rheumatoid arthritis (RA) and a common -168A>G polymorphism in the MHC2TA gene with differential major histocompatibility complex (MHC) II molecule expression was recently reported in a Swedish population. The objective of the present study was to replicate this finding by examining the -168A>G polymorphism in an Austrian case–control study. Three hundred and sixty-two unrelated RA cases and 351 sex-matched and age-matched controls as well as 1,709 Austrian healthy individuals were genotyped. All participants were from the same ethnic background. Genotyping was performed using 5' allelic discrimination assays. The association between susceptibility to RA and the -168A>G single nucleotide polymorphism was examined by chi-square test. Comparison was made assuming a dominant effect (AG + GG genotypes versus AA genotype). In contrast to the primary report, the frequency of MHC2TA -168G allele carriers was not significantly different between patients and controls in the Austrian cohort. The homozygous MHC2TA -168 GG genotype was more frequent in matched controls than in Austrian RA patients. There was no association between the presence of RA-specific autoantibodies and the MHC2TA -168 GG genotype. In this cohort of Austrian patients, no association between the MHC2TA polymorphism and RA was found.
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