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Arch Dis Child. 1987 October; 62(10): 1070–1072.
PMCID: PMC1778685

Carbon monoxide production in ventilated premature infants weighing less than 1500 g.


Mean pulmonary excretion rate of carbon monoxide in 13 premature babies on ventilators was significantly higher (p less than 0.001) than that of 19 healthy infants born at full term. This correlated with carboxyhaemoglobin concentrations in blood, indicating that the premature infants on ventilators produced abnormally large amounts of bilirubin.

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Selected References

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  • Cohen RS, Ostrander CR, Cowan BE, Stevens GB, Hopper AO, Stevenson DK. Pulmonary excretion rates of carbon monoxide using a modified technique: differences between premature and full-term infants. Biol Neonate. 1982;41(5-6):289–293. [PubMed]
  • Ostrander CR, Cohen RS, Hopper AO, Cowan BE, Stevens GB, Stevenson DK. Paired determinations of blood carboxyhemoglobin concentration and carbon monoxide excretion rate in term and preterm infants. J Lab Clin Med. 1982 Nov;100(5):745–755. [PubMed]
  • Maisels MJ, Pathak A, Nelson NM, Nathan DG, Smith CA. Endogenous production of carbon monoxide in normal and erythroblastotic newborn infants. J Clin Invest. 1971 Jan;50(1):1–8. [PMC free article] [PubMed]
  • Fällström SP. Endogenous formation of carbon monoxide in newborn infants. IV. On the relation between the blood carboxyhaemoglobin concentration and the pulmonary elimination of carbon monoxide. Acta Paediatr Scand. 1968 Jul;57(4):321–329. [PubMed]
  • Ostrander CR, Johnson JD, Bartoletti AL. Determing the pulmonary excretion rate of carbon monoxide in newborn infants. J Appl Physiol. 1976 May;40(5):844–848. [PubMed]
  • Vreman HJ, Kwong LK, Stevenson DK. Carbon monoxide in blood: an improved microliter blood-sample collection system, with rapid analysis by gas chromatography. Clin Chem. 1984 Aug;30(8):1382–1386. [PubMed]

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