This study demonstrates that the increase in circulating IL-6 concentration observed after coronary angioplasty results from a transmyocardial production occurring within the territory of the treated coronary vessel and is independent of any detectable sign of necrosis. This IL-6 release is significant two hours after the procedure, with a modest and insignificant increase being observed in the first seconds immediately following stent implantation.
Inflammation is an initial consequence of an angioplasty procedure, possibly triggered by the exposure of the thrombogenic surface of the vessel wall to circulating leucocytes and by the recruitment of inflammatory cells from the overstretched adventitia. In addition, stent deployment can cause a foreign body reaction, amplifying the inflammatory response.
Previous studies designed to measure the expression of inflammatory markers after angioplasty provided conflicting results. Liuzzo and colleagues3
showed that the rise of cytokine concentrations after PCI is determined by a pre-procedural individual hyper-responsive immune system and not by the plaque rupture. Cusack and colleagues4
showed that the intracardiac production of IL-6 in unstable angina could be the result of low grade myocardial necrosis. In these studies (except for one subgroup of the Cusack study), the blood samples for IL-6 concentration assessment were drawn from a peripheral site and not from the coronary sinus. This method did not allow a precise measurement of local myocardial cytokine production relating to the vascular trauma and the coronary stenting.
Hojo and colleagues5
demonstrated a relation between the rise of IL-6 concentration in the coronary sinus after PCI and the risk of late restenosis. No late blood sampling and no simultaneous measurement of arterial concentrations of IL-6 were carried out.
In our study, we used a carefully selected population, only including stable patients with a single short stenosis of the proximal segment of the left anterior descending coronary artery. All patients were treated with a single stent implantation in order to produce a standardised inflammatory stimulus. Samples were taken simultaneously from the aorta and the coronary sinus, which is the only method that assesses local transmyocardial production. Moreover, to confirm that the effluent of the treated vascular territory was adequately sampled in the coronary sinus, we measured lactate concentration on arterial and venous blood samples obtained immediately after stent implantation. In these conditions, a modest and insignificant transmyocardial IL-6 release is detectable immediately after stenting, but a sustained transmyocardial production is observed two hours after the procedure which is independent of any systemic troponin I concentration increase. This time course suggests that the increase in IL-6 circulating concentrations after PCI is related to an inflammatory response within the coronary vasculature occurring in the vascular territory directly affected by the procedure, most likely at the site of the stent implantation. The absence of any increase in troponin I concentration shows that this inflammatory reaction is not triggered by necrosis in underlying myocardial areas. The measurement of this local production of inflammatory mediators could help to quantify the reaction to various types of stent materials and the ability of drug eluting stents to prevent local inflammatory reaction after PCI.