The authors would like to thank Shin Lin, PhD for helpful discussions and Nulang Wang for DNA extraction and CFTR genotyping. Genotyping of the 402 marker STR map was done by the Mammalian Genotyping Service in the Center for Medical Genetics at the Marshfield Clinic (Marshfield, WI). This study would not be possible without CF patients and their families, Research Coordinators and CF Center Directors and Physicians participating in the CF Twin and Sibling Study. The following Centers are participants in the CF Twin and Sibling Study: Advocate Hope Children’s Hospital, Oak Lawn, IL; Children’s Hospital and Medical Center of Akron, Akron, OH; Children’s Asthma Respiratory & Exercise Specialists, Glenview, IL; Children’s Hospital and Medical Center of Cincinnati, Cincinnati, OH; Children’s Hospital and Medical Center, Seattle, WA; The Children’s Hospital of Boston, Boston, MA; Children’s Hospital of Buffalo, Buffalo, NY; Children’s Hospital of Denver, Denver, CO; Children’s Hospital of Los Angeles, Los Angeles, CA; Children’s Hospital of Oakland, CA; Children’s Hospital of Orange County, Orange, CA; Children’s Hospital of Philadelphia, Philadelphia, PA; Children’s Hospital of Pittsburgh, Pittsburgh, PA; Children’s Hospital of Wisconsin, Milwaukee, WI; Children’s Medical Center of Dallas, Dallas, TX; Children’s Memorial Medical Center, Chicago, IL; Children’s Mercy Hospital Kansas City, KS; Columbus Children’s Hospital, Columbus, OH; Connecticut Children’s Medical Center, Hartford, CT; Cook Children’s Medical Center, Fort Worth, TX; Dartmouth-Hitchcock Medical Center, Lebanon, NH; Eastern Maine Medical Center, Bangor, ME; Emory University School of Medicine, Atlanta, GA; Fletcher Allen Health Care, Burlington, VT; Georgia Pediatric Pulmonology Associates, Atlanta, GA; Great Falls Clinic, Great Falls, MT; Hasbro Children’s Hospital, Providence, RI; Hershey Medical Center, Hershey, PA; Hospital of the University of Pennsylvania, Philadelphia, PA; Joe DiMaggio Pulmonary Center, Hollywood, FL; Johns Hopkins Hospital, Baltimore, MD; Kaiser Permanente Medical Center, Oakland, CA; Kaiser Permanente, Portland, OR; Kaiser-Permanente, Panorama City, CA; Massachusetts General Hospital, Boston, MA; Medical College of Georgia, Augusta, GA; Medical University of South Carolina, Charleston, SC; Memphis Lung Physicians, South Haven, MS; Methodist Children’s Hospital, San Antonio, TX; Methodist Hospital, Houston, TX; Michigan State University, Lansing, MI; Monmouth Medical Center, Long Branch, NJ; Morristown Memorial Hospital, NJ; Mountain State CF Center, Morgantown, WV; National Naval Medical Center, Bethesda, MD; Naval Medical Center San Diego, San Diego, CA; New York Medical College, Valhalla, NY; Oklahoma Health Science Center, Oklahoma City, OK; Pediatric Diagnostic Center, Ventura, CA; Pediatric Pulmonary Associates, Columbia, SC; The Prince Charles Hospital, Australia; Rainbow Babies and Children’s Hospital, Cleveland, OH; Riley Children’s Hospital, Indianapolis, IN; Royal Hospital for Sick Children, Yorkhill, Scotland; Rush Presbyterian St Luke’s Medical Center, Chicago, IL; Saint Vincent’s Hospital & Medical Center, New York, NY; Schneider Children’s Hospital, New Hyde Park, NY; Sparks Regional Medical Center, Fort Smith, AK; St Christopher’s Hospital for Children, Philadelphia, PA; St Mary’s Medical Center, West Palm Beach, FL; St. Louis Children’s Hospital, St. Louis, MO; Stanford University Medical Center, Palo Alto, CA; SUNY Pediatric Pulmonary & CF Center, Syracuse, NY; Sutter Medical Center, Sacramento, CA; TC Thompson Children’s Hospital, Chattanooga, TN; Texas Children’s Hospital, Houston TX; University of Alabama CF Center, Birmingham, AL; University of Arizona, Tucson, AZ; University of California at San Francisco; University of Iowa Hospitals and Clinics, Iowa City, IA; University of Kentucky, Lexington, KY; University of Massachusetts Medical School, Worcester, MA; University of Michigan, Ann Arbor, MI; University of Minnesota, Minneapolis, MN; University of Mississippi Medical Center, Jackson, MS; University of Nebraska, Omaha, NE; University of New Mexico Health Sciences Center, Albuquerque, NM; University of North Carolina, Chapel Hill, NC; University of Tennessee, Memphis, TN; University of Texas Health Center, Tyler TX; University of Utah, Salt Lake City, UT; University of Virginia Health System, Charlottesville, VA; University of Wisconsin Hospital, Madison, WI; Vanderbilt University Medical Center, Nashville, TN; Wake Forest University, Baptist Medical Center, Winston-Salem, NC; Wayne State University School of Medicine, Detroit, MI; Western Carolina CF Center, Charlotte, NC; Wichita Clinic, PA, Wichita, KS; Wilford Hall Medical Center, San Antonio, TX; Yale University, New Haven, CT.
This work was funded by grant HL 68927 from the National Institute of Heart, Lung and Blood and by grant CUTTIN00A0 from the U.S. Cystic Fibrosis Foundation.