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J Clin Pathol. Aug 2000; 53(8): 636–638.
PMCID: PMC1762914
Haemophagocytic syndrome and histiocytic necrotising lymphadenitis (Kikuchi's disease)
U Mahadeva, T Allport, B Bain, and W Chan
Department of Histopathology, St Mary's Hospital, London, UK.
A young boy presented with a rash, fever, and cervical lymphadenopathy, originally thought to be caused by tuberculosis. A lymph node biopsy showed the features of Kikuchi's disease, with necrosis and histiocytic infiltration without neutrophils. No evidence of tuberculosis was found on staining, culture, or the polymerase chain reaction. Bone marrow biopsy revealed prominent haemophagocytosis, and a diagnosis of haemophagocytic syndrome was reached. The aetiology of haemophagocytic syndrome, and its association with Kikuchi's lymphadenitis, is discussed.
Key Words: Kikuchi's disease • histiocytic necrotising lymphadenitis • histiocytic haemophagocytosis • haemophagocytic syndrome
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Figure 1 Lymph node biopsy showed sharply demarcated areas of necrosis, with infiltration by histiocytes and lymphoblasts (haematoxylin and eosin stain).
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Figure 2 Bone marrow aspirate showed haemophagocytic histiocytes (May Grünwald Giemsa stain).
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