Entrez Gene is the gene-specific database at the National Center for Biotechnology Information (NCBI), a division of the National Library of Medicine (NLM), located on the campus of the US National Institutes of Health (NIH) in Bethesda, MD, USA. Entrez Gene provides unique integer identifiers for genes and other loci (such as officially named mapped markers) for a subset of model organisms. It tracks those identifiers, and is integrated with the Entrez system for interactive query, LinkOut and access by E-Utilities (1
). The information that is maintained includes nomenclature, defining sequence, chromosomal localization, gene products and their attributes (e.g. protein interactions), associated markers, phenotypes, interactions and a wealth of links to citations, related sequences, variation, maps, expression, homologs, protein domain content and external databases.
Data in Entrez Gene result from a mixture of curation by RefSeq staff and automated analyses. Annotation in sequences from NCBI's Reference sequence project (2
) or the International Nucleotide Sequence Database Collaboration (DDBJ, EMBL, GenBank) (3
) is integrated with information from collaborating model organism databases, public users and literature review (especially the Gene References into Function or GeneRIFs).
Entrez Gene is an integral part of representation of gene-specific information at NCBI. The information conveyed by establishing the relationship between sequence and a GeneID is used by other NCBI resources (1
) such as BLAST, dbSNP, GEO, HomoloGene, Map Viewer, Probe, UniGene, UniSTS and NCBI's genome annotation pipeline. For example, the names associated with GeneIDs are used in HomoloGene, UniGene and the Mammalian Gene Collection (4
). Inconsistencies in representation of genes and their sequences are investigated, and resolved by NCBI RefSeq staff in consultation with multiple authorities (2
). Although providing a stable interface is a goal of Entrez Gene, the content, display or methods for bulk transfer may change. One method to receive advanced notification of changes is via subscription to gene-announce/at/ncbi.nlm.nih.gov